Correlation between the corpus callosum index and brain atrophy, lesion load, and cognitive dysfunction in multiple sclerosis
| Autor: | Gustavo H Tomasi, Luciana Schermann Azambuja, Douglas Kazutoshi Sato, Alexandre Rosa Franco, Jefferson Becker, Irenio Gomes, Jorge Luiz Palmeiro Burger, Lucas Immich Gonçalves, Manuella Edler Zandona, Giordani Rodrigues dos Passos, Lucas Piccoli Conzatti |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Paced Auditory Serial Addition Test Corpus callosum 030218 nuclear medicine & medical imaging White matter Lesion 03 medical and health sciences Disability Evaluation 0302 clinical medicine Atrophy Multiple Sclerosis Relapsing-Remitting Image Interpretation Computer-Assisted medicine Humans Cognitive Dysfunction Gray Matter Expanded Disability Status Scale medicine.diagnostic_test business.industry Multiple sclerosis Brain Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging White Matter nervous system diseases medicine.anatomical_structure Cross-Sectional Studies Neurology Female Neurology (clinical) medicine.symptom business Nuclear medicine psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Multiple sclerosis and related disorders. 20 |
| ISSN: | 2211-0356 |
| Popis: | Background The corpus callosum index (CCI) can be easily and reliably obtained from conventional magnetic resonance imaging (MRI) and has been proposed as a possible marker of brain atrophy in MS. However, further validation of its correlation with volumetric measurements is still warranted. Objective To assess the correlation of the CCI with the corpus callosum volume (CCV), brain and lesion volumes, and level of disability in MS. Methods Cross-sectional, exploratory study including patients with relapsing-remitting MS. Clinical assessment comprised of physical and cognitive disability scales. MRI parameters included conventional volumetric measurements, the CCI (manual), and the CCV (automated). Results Twenty-four patients were included. There was a strong correlation between the CCI and CCV. The CCI correlated strongly with the white matter and lesion volumes, and moderately with the whole brain volume and scores on the Paced Auditory Serial Addition Test and MS Functional Composite. There were no correlations between the CCI and either gray matter volume or scores on the Expanded Disability Status Scale, the 9-Hole Peg Test, or the Timed 25-Foot Walk test. Conclusion The findings support the validity of the CCI as an easy-to-obtain marker of brain atrophy, lesion load, and cognitive dysfunction in patients with MS. |
| Databáze: | OpenAIRE |
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