Corneal Allogenic Intrastromal Ring Segments (CAIRS) Combined With Corneal Cross-linking for Keratoconus
| Autor: | Soosan Jacob, A I Saijimol, John Michael Raj, Amar Agarwal, Arvind Ramalingam, Shaila R Patel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Keratoconus medicine.medical_specialty Visual acuity genetic structures Corneal Pachymetry Ultraviolet Rays Corneal Stroma Riboflavin Visual Acuity Pilot Projects Refraction Ocular law.invention 03 medical and health sciences Young Adult 0302 clinical medicine law Cornea Ophthalmology medicine Humans Transplantation Homologous Corneal pachymetry Photosensitizing Agents medicine.diagnostic_test Keratometer business.industry Corneal Topography Corneal topography medicine.disease Combined Modality Therapy eye diseases Tissue Donors Transplantation 030104 developmental biology medicine.anatomical_structure Cross-Linking Reagents Trephine Photochemotherapy 030221 ophthalmology & optometry Surgery Female sense organs medicine.symptom business |
| Zdroj: | Journal of refractive surgery (Thorofare, N.J. : 1995). 34(5) |
| ISSN: | 1081-597X |
| Popis: | PURPOSE: To describe a new technique for the treatment of keratoconus using corneal allogenic intrastromal ring segments (CAIRS). METHODS: CAIRS trephined from donor cornea using a double-bladed trephine were implanted into mid-depth femtosecond laser–dissected channels in the cornea of patients with keratoconus in the 6.5-mm optic zone, followed by accelerated corneal cross-linking (A-CXL)—either conventional or contact lens–assisted CXL (A-CACXL), depending on minimum corneal thickness. RESULTS: Twenty patients (24 eyes) with stage 1 to 4 keratoconus (Amsler–Krumeich grading) were included. Mean follow-up was 11.58 ± 3.6 months (range: 6 to 18 months). There was significant improvement in uncorrected (2.79 ± 2.65 lines; range: 0 to 8 lines) and corrected (1.29 ± 1.33 lines; range: 0 to 5 lines) distance visual acuity, spherical equivalent, simulated maximum keratometry, steepest keratometry, topographic astigmatism, anterior and posterior best fit spheres, and mean power in the 3- and 5-mm zones. No eye showed progression during the entire follow-up. All segments remained well positioned and no segment-induced complications were seen. No other major intraoperative or postoperative complications were observed. CONCLUSIONS: This pilot study indicates that CAIRS with CXL may be a simple, safe, and effective option for treating keratoconus. Further studies are recommended to determine long-term outcomes. [ J Refract Surg. 2018;34(5):296–303.] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|