Central effects of humanin on hepatic triglyceride secretion
| Autor: | Ting Zhang, Zhenwei Gong, Kai Su, H. Henry Dong, Radhika Muzumdar, Lingguang Cui, Emir Tas, Shoshana Yakar |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Peptide Endogeny Intra-Abdominal Fat Biology Diet High-Fat Models Biological Rats Sprague-Dawley chemistry.chemical_compound Vagotomy Truncal Physiology (medical) Internal medicine medicine Animals Secretion Obesity Infusions Intravenous Cells Cultured Triglycerides Adiposity Humanin chemistry.chemical_classification Triglyceride Intracellular Signaling Peptides and Proteins Reproducibility of Results Articles Mice Inbred C57BL Infusions Intraventricular Endocrinology Liver chemistry Hypothalamus Hepatocytes Anti-Obesity Agents Carrier Proteins Peptides Central Nervous System Agents |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 309:E283-E292 |
| ISSN: | 1522-1555 0193-1849 |
| Popis: | Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown to protect against various Alzheimer's disease-associated insults, myocardial ischemia-reperfusion injury, and reactive oxygen species-induced cell death. We have shown previously that HN improves whole body glucose homeostasis by improving insulin sensitivity and increasing glucose-stimulated insulin secretion (GSIS) from the β-cells. Here, we report that intraperitoneal treatment with one of HN analogs, HNG, decreases body weight gain, visceral fat, and hepatic triglyceride (TG) accumulation in high-fat diet-fed mice. The decrease in hepatic TG accumulation is due to increased activity of hepatic microsomal triglyceride transfer protein (MTTP) and increased hepatic TG secretion. Both intravenous (iv) and intracerebroventricular (icv) infusion of HNG acutely increase TG secretion from the liver. Vagotomy blocks the effect on both iv and icv HNG on TG secretion, suggesting that the effects of HNG on hepatic TG flux are centrally mediated. Our data suggest that HN is a new player in central regulation of peripheral lipid metabolism. |
| Databáze: | OpenAIRE |
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