Hydroxyl-radical-dependent DNA damage by ambient particulate matter from contrasting sampling locations
| Autor: | Tingming Shi, Christel Weishaupt, Paul J. A. Borm, Hui Li, Rodger Duffin, Roel P. F. Schins |
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| Rok vydání: | 2005 |
| Předmět: |
DNA damage
Radical Biochemistry Cell Line chemistry.chemical_compound Germany Humans Particle Size General Environmental Science A549 cell Air Pollutants Dimethyl sulfoxide Hydroxyl Radical Electron Spin Resonance Spectroscopy 8-Hydroxy-2'-deoxyguanosine Deoxyguanosine Dust DNA Particulates Molecular biology chemistry 8-Hydroxy-2'-Deoxyguanosine Hydroxyl radical DNA Damage Environmental Monitoring |
| Zdroj: | Environmental research. 101(1) |
| ISSN: | 0013-9351 |
| Popis: | Exposure to ambient particulate matter (PM) has been reported to be associated with increased respiratory, cardiovascular, and malignant lung disease. Previously we have shown that PM can induce oxidative DNA damage in A549 human lung epithelial cells. The aims of the present study were to investigate the variability of the DNA-damaging properties of PM sampled at different locations and times and to relate the observed effects to the hydroxyl-radical (OH)-generating activities of these samples. Weekly samples of coarse (10-2.5 microm) and fine ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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