Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers
| Autor: | Fernanda Guedes Rodrigues, Rodrigo Fernandes Carvalho Azambuja Neves, Milene Subtil Ormanji, Priscila Ligeiro Gonçalves Esper, Melissa Gaspar, Rosa Maria Rodrigues Pereira, Lucio R. Requião-Moura, Martin H. de Borst, Ita Pfeferman Heilberg |
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| Přispěvatelé: | Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC) |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of personalized medicine, 12(7):1120. MDPI AG Journal of Personalized Medicine; Volume 12; Issue 7; Pages: 1120 |
| ISSN: | 2075-4426 |
| DOI: | 10.3390/jpm12071120 |
| Popis: | Background: Nephrolithiasis has been associated with bone loss and vascular calcification (VC), reflecting abnormal extraosseous calcium deposition. Fetuin-A (Fet-A) acts as a potent inhibitor of ectopic mineralization. The aim of the present study was to evaluate the prevalence of VC in stone formers (SF) and non-stone formers (NSF) and to investigate potential determinants of VC among SF, including circulating levels of Fet-A and bone microarchitecture parameters. Methods: Abdominal aortic calcification (AAC) was assessed using available computed tomography in SF and in age-, sex-, and BMI-matched NSF (potential living kidney donors). Serum Fet-A was measured in stored blood samples from SF. Bone microarchitecture parameters were obtained as a post hoc analysis of a cross-sectional cohort from young SF evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). Results: A total of 62 SF (38.0 [28.0–45.3] years old) and 80 NSF (40.0 [37.0–45.8] years old) were included. There was no significant difference in AAC scores between SF and NSF. However, when dividing SF according to mean AAC score, below |
| Databáze: | OpenAIRE |
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