HLA class I in acute promyelocytic leukemia (APL): possible correlation with clinical outcome
| Autor: | Patricia Momigliano-Richiardi, K Fleischhauer, Sandra D'Alfonso, Giuseppe Cimino, G Migliaretti, Daniela Diverio, Elisabetta Bolognesi, M. C. Rapanotti |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Risk Acute promyelocytic leukemia Cancer Research Genotype Oncogene Proteins Fusion Tretinoin Peptide binding HLA-C Antigens Human leukocyte antigen Biology Gene Frequency Leukemia Promyelocytic Acute Antigens Neoplasm Antineoplastic Combined Chemotherapy Protocols medicine Humans Idarubicin Genetic Predisposition to Disease Allele Allele frequency HLA-B13 Antigen HLA-A Antigens Remission Induction Hematology Middle Aged Prognosis medicine.disease Neoplasm Proteins Leukemia Treatment Outcome Italy Oncology HLA-B Antigens Immunology Neoplastic Stem Cells Female Neoplasm Recurrence Local medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1476-5551 0887-6924 |
| DOI: | 10.1038/sj.leu.2401691 |
| Popis: | The majority of patients with acute promyelocytic leukemia (APL) possess either a bcr1 or a bcr3 type fusion between PML and RARalpha genes. The junction sequences may possibly be a target for immune response and influence susceptibility to the disease. In this case, HLA class I allele frequencies would be different between bcr1 and bcr3 patients. To test this hypothesis, we typed 102 APL patients for HLA-A, -B and -Cw alleles. The A*1, A*30, B*51, B*41, Cw*0602, and Cw*1701 alleles showed a different distribution between bcr1 and bcr3 patients, but in no case was this statistically significant after correction for the number of comparisons or was confirmed in an independent panel. Moreover, no difference was detected between bcr1 and bcr3 when HLA alleles were grouped according to their peptide binding specificities. Comparing HLA frequencies, clinical features at diagnosis and clinical outcome of the 64 patients homogeneously treated with all-trans retinoic acid and idarubicin (AIDA protocol) we observed a statistically significant association between HLA-B*13 and risk of relapse by univariate and multivariate regression analysis. Should this finding be confirmed in larger future studies, this observation would be of outmost importance in identifying patients at high risk of relapse in which more aggressive consolidation therapies should be used. |
| Databáze: | OpenAIRE |
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