Systemic inflammation in patients with compromised upper airway anatomy and primary snoring or mild obstructive sleep apnea
| Autor: | Christoph Jahn, Christoph Matthias, Haralampos Gouveris |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Polysomnography 030204 cardiovascular system & hematology Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Child Aged Retrospective Studies Aged 80 and over Inflammation Sleep Apnea Obstructive medicine.diagnostic_test Respiratory distress biology business.industry Snoring C-reactive protein Fibrinogen Apnea Sleep apnea Retrospective cohort study General Medicine Middle Aged medicine.disease respiratory tract diseases Obstructive sleep apnea C-Reactive Protein Otorhinolaryngology Anesthesia biology.protein Female medicine.symptom business Hypopnea 030217 neurology & neurosurgery |
| Zdroj: | European Archives of Oto-Rhino-Laryngology. 273:3429-3433 |
| ISSN: | 1434-4726 0937-4477 |
| DOI: | 10.1007/s00405-016-4103-5 |
| Popis: | Our aim was to study associations between serum fibrinogen and C-reactive protein (CRP) levels and respiratory parameters on polysomnography (PSG) in patients with snoring as their main complaint and compromised upper airway anatomy. In this retrospective study, consecutive patients (43 female and 132 male; age range 11-82 years, respiratory distress index-RDI range 0.1-94.4/h) with snoring as their main complaint and compromised upper airway anatomy who underwent PSG were assessed. Spearman's Rho coefficients between RDI, AI (apnea index), hypopnea index (HI), average and lowest SpO2 (in %) and CRP- and fibrinogen serum levels were calculated. Comparisons between groups were made using Wilcoxon-W test. Patients with CRP 5 mg/dl (22 % of the cohort) had significantly increased RDI, AI, average and lowest SpO2 than patients with CRP 5 mg/dl. Increased correlation coefficients were observed for average SpO2 (-0.386), RDI (0.355), lowest SpO2 (-0.323) and AI (0.309). Patients with fibrinogen350 mg/dl (in 33 %) had significantly increased RDI, HI, AI, average and lowest SpO2 than patients with fibrinogen350 mg/dl. Increased correlation coefficients were found for average (-0.340) and lowest (-0.268) SpO2, RDI (0.236) and AI (0.229). Even patients with RDI 15/h had increased serum CRP-(in 11 %) and/or fibrinogen-(in 19 %) levels. Simultaneous elevation of both CRP and fibrinogen levels occurred only in patients with RDI 5/h. Systemic inflammation is strongly associated with average and lowest SpO2, RDI and AI (and with HI) in snorers with compromised upper airway anatomy and is present even in patients with primary snoring and mild obstructive sleep apnea. |
| Databáze: | OpenAIRE |
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