In vitro synergistic combinations of pentamidine, polymyxin B, tigecycline and tobramycin with antifungal agents against Fusarium spp
| Autor: | Jéssica Tairine Keller, Tarcieli Pozzebon Venturini, Janio Morais Santurio, Francieli Chassot, Sydney Hartz Alves, Luana Rossato, Fernanda Baldissera Piasentin |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Itraconazole 030106 microbiology Microbial Sensitivity Tests Pharmacology Microbiology 03 medical and health sciences chemistry.chemical_compound Anti-Infective Agents Fusarium Amphotericin B Tobramycin Humans Medicine Pentamidine Voriconazole business.industry Broth microdilution Drug Synergism General Medicine chemistry Caspofungin business Polymyxin B medicine.drug |
| Zdroj: | Journal of Medical Microbiology. 65:770-774 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.000301 |
| Popis: | The genus Fusarium is characterized by hyaline filamentous fungi that cause infections predominantly in immunocompromised patients. The remarkable primary resistance to antifungal agents of this genus requires a search for new therapeutic possibilities. This study assessed the in vitro susceptibility of 25 clinical isolates of Fusarium against antifungal agents (amphotericin B, caspofungin, itraconazole and voriconazole) and antimicrobials (pentamidine, polymyxin B, tigecycline and tobramycin) according to the broth microdilution method (M38-A2). The interactions between antifungal and antimicrobial agents were evaluated by the microdilution checkerboard method. Pentamidine and polymyxin B showed MIC values ≥4 µg ml-1 against Fusarium spp. The highest rates of synergism were observed when amphotericin B or voriconazole was combined with tobramycin (80 % and 76 %, respectively), polymyxin B (76 % and 64 %) and pentamidine (72 % and 68 %). The most significant combinations deserve in vivo evaluations in order to verify their potential in the treatment of fusariosis. |
| Databáze: | OpenAIRE |
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