High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival
| Autor: | Sylvia Stadlmann, Salvatore Piscuoglio, Alexander Wilhelm, Ornella Neri, Alexandros Lalos, Raoul A. Droeser, Caner Ercan, Gad Singer, Benjamin Weixler, Alberto Posabella, Sebastian Staubli, Luigi Terracciano, Giulio C. Spagnoli |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Myeloid recurrence medicine.medical_treatment chemical and pharmacologic phenomena Article Internal medicine medicine RC254-282 Chemotherapy Tissue microarray tissue microarray business.industry Standard treatment Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Debulking medicine.anatomical_structure ovarian cancer immunohistochemistry biomarker prognosis Ovarian cancer business Recurrent Ovarian Carcinoma CD16 |
| Zdroj: | Cancers, Vol 13, Iss 5783, p 5783 (2021) Cancers Volume 13 Issue 22 |
| ISSN: | 2072-6694 |
| Popis: | Background: Ovarian cancer (OC) is the most aggressive and fatal malignancy of the female reproductive system. Debulking surgery with adjuvant chemotherapy represents the standard treatment, but recurrence rates are particularly high. Over the past decades, the association between the immune system and cancer progression has been extensively investigated. However, the interaction between chemotherapy and cancer immune infiltration is still unclear. In this study, we examined the prognostic role of CD16 expression in OC, as related to the effectiveness of standard adjuvant chemotherapy treatment. Methods: We analyzed the infiltration by immune cells expressing CD16, a well-characterized natural killer (NK) and myeloid cell marker, in a tissue microarray (TMA) of 47 patient specimens of primary OCs and their matching recurrences by immunohistochemistry (IHC). We analyzed our data first in the whole cohort, then in the primary tumors, and finally in recurrences. We focused on recurrence-free survival (RFS), overall survival (OS), and chemosensitivity. Chemosensitivity was defined as RFS of more than 6 months. Results: There was no significant correlation between CD16 expression and prognosis in primary carcinomas. However, interestingly, a high density of CD16-expressing tumor-infiltrating immune cells (TICs) in recurrent carcinoma was associated with better RFS (p = 0.008) and OS (p = 0.029). Moreover, high CD16 cell density in recurrent ovarian carcinoma showed a significant association with chemosensitivity (p = 0.034). Univariate Cox regression analysis revealed that the high expression of CD16+ TIC in recurrent cancer biopsies is significantly associated with an increased RFS (HR = 0.49 95% CI 0.24–0.99 p = 0.047) and OS (HR = 0.28 95% CI 0.10–0.77 p = 0.013). However, this was not independent of known prognostic factors such as age, FIGO stage, resection status, and the number of chemotherapy cycles. Conclusions: The high density of CD16-expressing TICs in recurrent ovarian cancer is associated with a better RFS and OS, thereby suggesting a previously unsuspected interaction between standard OC chemotherapy and immune cell infiltration. |
| Databáze: | OpenAIRE |
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