Non-aqueous formulations for ram and screen extrusion-spheronisation
| Autor: | M. Zhang, C. Seiler, R. Ward, S.L. Rough, D.I. Wilson |
|---|---|
| Přispěvatelé: | Wilson, Ian [0000-0003-3950-9165], Apollo - University of Cambridge Repository |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Pellets Chemistry Pharmaceutical Drug Compounding Plastics extrusion Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Calcium Carbonate Spheronisation 2-Propanol Excipients 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Non-aqueous formulations Technology Pharmaceutical Cellulose Particle Size Active ingredient Aqueous solution Hydroxypropyl cellulose Extrusion Isopropyl alcohol 021001 nanoscience & nanotechnology chemistry Chemical engineering 0210 nano-technology |
| DOI: | 10.17863/cam.36601 |
| Popis: | The use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was identified as a suitable sticky liquid binder for preparing non-aqueous pastes. Preliminary tests were performed on a series of pastes using a ram as well as a laboratory roller screen extruder, since the former is commonly used in batch testing and the latter replicates the shear range in a manufacturing screen extruder. Pellets with acceptable size and shape distributions were obtained with Avicel® HFE-102 NF/HPC/IPA for ram E-S, and with Avicel® RC-591/HPC/IPA for screen E-S. Further investigation was performed with calcium carbonate added as a model active pharmaceutical ingredient. Both formulations were able to generate pellets with acceptable size and shape characteristics at up to 50 wt% carbonate loading: further work is required to optimise yields. |
| Databáze: | OpenAIRE |
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