Effect of Platelet-Rich Plasma on Nonsurgically Treated Acute Achilles Tendon Ruptures: A Randomized, Double-Blinded Prospective Study
| Autor: | Peter Malliaras, Anders Lenskjold, Kristoffer Weisskirchner Barfod, Anders Ploug Boesen, Morten Ilum Boesen, Rudi Hansen, Henning Langberg |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Double blinded Physical Therapy Sports Therapy and Rehabilitation Achilles Tendon Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Tendon Injuries Tendon elongation Humans Medicine Orthopedics and Sports Medicine Prospective Studies Prospective cohort study Tendon healing Rupture 030222 orthopedics Achilles tendon Platelet-Rich Plasma business.industry 030229 sport sciences Middle Aged Surgery Treatment Outcome medicine.anatomical_structure Platelet-rich plasma Achilles tendon rupture medicine.symptom business |
| Zdroj: | The American Journal of Sports Medicine. 48:2268-2276 |
| ISSN: | 1552-3365 0363-5465 |
| Popis: | Background: An acute Achilles tendon rupture (ATR) is a long-lasting and devastating injury. Possible biological augmentation to promote and strengthen tendon healing after an ATR would be desirable. Purpose: To determine whether the application of a platelet-rich plasma (PRP) injection in nonsurgically treated ATRs may promote healing and thereby improve functional outcomes. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 40 men (aged 18-60 years) with an ATR incurred within 72 hours were included, and 38 were followed for 12 months. All patients were treated with an orthosis with 3 wedges for 8 weeks; full weightbearing from day 1 was allowed, combined with either 4 PRP or 4 placebo injections (a few drops of saline, Results: The mean ATRS score improved in both groups at all time points ( P < .001), but there was no difference between the groups at any time points (12 months: 90.1 points in PRP group and 88.8 points in placebo group). No differences in all functional outcomes at any time points were seen between the groups. At 12 months, the injured leg did not reach normal functional values compared with the uninjured leg. Conclusion: The application of PRP in nonsurgically treated ATRs did not appear to show any superior clinical and functional improvement. Registration: NCT02417922 (ClinicalTrials.gov identifier) |
| Databáze: | OpenAIRE |
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