Analysis of MMP-3 polymorphism in osseointegrated implant failure
| Autor: | Paula Regina Bach Nogara, Filipe Polese Branco, Maria Cristina Leme Godoy dos Santos, Francisco Rafael da Costa Costa Junior, Francielle Boçon de Araujo Munhoz |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
business.industry medicine.medical_treatment Implant failure Connective tissue RK1-715 030206 dentistry Matrix metalloproteinase Bioinformatics Osseointegration 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Dentistry Genotype medicine Polymorphism. Metalloproteinase. Implant loss. Risk factor Implant Oral mucosa Dental implant business General Dentistry |
| Zdroj: | Brazilian Journal of Oral Sciences, Vol 15, Iss 4 (2017) |
| ISSN: | 1677-3225 |
| DOI: | 10.20396/bjos.v15i4.8650045 |
| Popis: | Polymorphisms in matrix metalloproteinases (MMPs) genes have been associated with several pathologies, including dental implant loss. MMP-3 is crucial to the connective tissue remodeling process. The objective of this study was to investigate the possible relationship between -1612 MMP-3 polymorphism and the early implant failure. A sample of 240 non-smokers was divided: test group 120 patients with one or more early failed implants and control group 120 patients with one or more healthy implants. Genomic DNA from oral mucosa was analyzed by PCR-RFLP. No association of early implant loss with genotypes and alleles of the -1612 polymorphism in MMP-3 were found by the Chi-squared test. Only the presence of the -1612 polymorphism of MMP-3 is not a genetic risk factor for early loss of implants. |
| Databáze: | OpenAIRE |
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