A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies
| Autor: | Namanjeet Ahluwalia, Stephen T. Holgate, Ascensión Marcos, Judith Moreines, Dirk Haller, R.J.J. van Neerven, Ruud Albers, Nabil Bosco, Bernhard Watzl, Philip C. Calder, Raphaëlle Bourdet-Sicard, J. Zhao, Michael Müller, C. M'Rini, Graham Pawelec, Marie E. Latulippe, Lena S. Jönsson |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Chemokine
endoplasmic-reticulum stress coronary-artery-disease medicine.medical_treatment Population Medicine (miscellaneous) Inflammation Celbiologie en Immunologie necrosis-factor-alpha Basal (phylogenetics) blood mononuclear-cells plasma il-6 levels Voeding Metabolisme en Genomica Voeding c-reactive protein Immunity low-grade inflammation Humans Medicine Nutritional Physiological Phenomena education Nutrition VLAG Global Nutrition education.field_of_study ischemic-heart-disease Wereldvoeding Nutrition and Dietetics biology business.industry C-reactive protein Metabolism and Genomics Diet Cytokine Cell Biology and Immunology Food Metabolisme en Genomica Immunology biology.protein WIAS Biomarker (medicine) Nutrition Metabolism and Genomics systemic-lupus-erythematosus medicine.symptom business obstructive pulmonary-disease Biomarkers |
| Zdroj: | British Journal of Nutrition, 109(S1), S1-S34 British Journal of Nutrition 109 (2013) S1 Digital.CSIC. Repositorio Institucional del CSIC instname ResearcherID |
| ISSN: | 0007-1145 |
| Popis: | To monitor inflammation in a meaningful way, the markers used must be valid: they must reflect the inflammatory process under study and they must be predictive of future health status. In 2009, the Nutrition and Immunity Task Force of the International Life Sciences Institute, European Branch, organized an expert group to attempt to identify robust and predictive markers, or patterns or clusters of markers, which can be used to assess inflammation in human nutrition studies in the general population. Inflammation is a normal process and there are a number of cells and mediators involved. These markers are involved in, or are produced as a result of, the inflammatory process irrespective of its trigger and its location and are common to all inflammatory situations. Currently, there is no consensus as to which markers of inflammation best represent low-grade inflammation or differentiate between acute and chronic inflammation or between the various phases of inflammatory responses. There are a number of modifying factors that affect the concentration of an inflammatory marker at a given time, including age, diet and body fatness, among others. Measuring the concentration of inflammatory markers in the bloodstream under basal conditions is probably less informative compared with data related to the concentration change in response to a challenge. A number of inflammatory challenges have been described. However, many of these challenges are poorly standardised. Patterns and clusters may be important as robust biomarkers of inflammation. Therefore, it is likely that a combination of multiple inflammatory markers and integrated readouts based upon kinetic analysis following defined challenges will be the most informative biomarker of inflammation. Copyright © ILSI Europe 2013. |
| Databáze: | OpenAIRE |
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