Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up

Autor: Sorin Giusca, Daniel J. Lenihan, Arne Kristian Schwarz, Grigorios Korosoglou, Henning Steen, Pia Wülfing, Susan Dent, Blaž Matija Geršak, Sebastian Kelle, Moritz Montenbruck, Sebastian Esch
Rok vydání: 2021
Předmět:
Male
Time Factors
T2 mapping
030204 cardiovascular system & hematology
Ventricular Function
Left
0302 clinical medicine
Natriuretic Peptide
Brain
Prospective Studies
medicine.diagnostic_test
biology
troponin
Middle Aged
030220 oncology & carcinogenesis
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Cardiology
biomarker
Biomarker (medicine)
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Heart Diseases
cardiotoxicity
Magnetic Resonance Imaging
Cine
Early detection
Antineoplastic Agents
Breast Neoplasms
03 medical and health sciences
Predictive Value of Tests
Internal medicine
myocardium
medicine
Humans
Radiology
Nuclear Medicine and imaging
Aged
Cardiotoxicity
business.industry
Troponin I
Magnetic resonance imaging
Imaging study
Original Articles
Myocardial Contraction
mortality
Troponin
Early Diagnosis
Myocardial strain
biology.protein
business
Biomarkers
Follow-Up Studies
Zdroj: Circulation. Cardiovascular Imaging
ISSN: 1942-0080
1941-9651
DOI: 10.1161/circimaging.121.012459
Popis: Supplemental Digital Content is available in the text.
Background: Our goal was to evaluate the ability of cardiovascular magnetic resonance for detecting and predicting cardiac dysfunction in patients receiving cancer therapy. Left ventricular ejection fraction, global and regional strain utilizing fast-strain-encoded, T1 and T2 mapping, and cardiac biomarkers (troponin and BNP [brain natriuretic peptide]) were analyzed. Methods: Sixty-one patients (47 with breast cancer, 11 with non-Hodgkin lymphoma, and 3 with Hodgkin lymphoma) underwent cardiovascular magnetic resonance scans at baseline and at regular intervals during 2 years of follow-up. The percentage of all left ventricular myocardial segments with strain ≤−17% (normal myocardium [%]) was analyzed. Clinical cardiotoxicity (CTX) and sub-CTX were defined according to standard measures. Results: Nine (15%) patients developed CTX, 26 (43%) had sub-CTX. Of the 35 patients with CTX or sub-CTX, 24 (69%) were treated with cardioprotective medications and showed recovery of cardiac function. The amount of normal myocardium (%) exhibited markedly higher accuracy for the detection of CTX and sub-CTX compared with left ventricular ejection fraction, T1, and T2 mapping as well as troponin I (Δareas under the curve=0.20, 0.24, and 0.46 for normal myocardium (%) versus left ventricular ejection fraction, troponin I, and T1 mapping, P
Databáze: OpenAIRE
Externí odkaz: