Clinicopathologic and immunohistochemical features of oral neurofibroma
| Autor: | Alexandra Fontes, Luciana Sassa Marocchio, Suzana Cantanhede Orsini Machado de Sousa, Fábio Daumas Nunes, Marcia Sampaio Campos |
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| Přispěvatelé: | Nunes, Fabio Daumas https://orcid.org/0000-0002-7785-6785, Nunes, Fabio Daumas/B-4543-2011, Sousa, Suzana/H-6154-2012, Campos, Marcia/D-9574-2012 |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty CD34 Peripheral-Nerve Neck Region Biology Antigen Tongue Nerve Sheath Tumors Dentistry Oral Surgery & Medicine medicine Humans Neurofibroma General Dentistry Oral Cavity General Medicine Differential Diagnosis Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Benign Cytoplasm Clinicopathological Aspects Female Mouth Neoplasms Differential diagnosis Head Biomarkers Immunostaining |
| Zdroj: | Web of Science Repositório Institucional da UNITAU Universidade de Taubaté (UNITAU) instacron:UNITAU |
| ISSN: | 1502-3850 0001-6357 |
| DOI: | 10.3109/00016357.2011.640286 |
| Popis: | Made available in DSpace on 2019-09-12T16:57:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2012 Objective. The purposes of this study were to assess clinical, histopathological and immunohistochemical features of 22 oral neurofibromas (NFs) and discuss with previously described literature, addressing the main aspects regarding the differential diagnosis. Materials and methods. Immunohistochemical reactions included S-100, CD34, GLUT-1, EMA, Ki-67, p53 and Collagen IV and histochemical reactions for Alcian blue. Results. Clinically, the preferential location was the maxillary bones, tongue and buccal mucosa. Microscopically, widely spread spindle-shaped cells with scant cytoplasm and elongated nuclei were observed. Immunostaining revealed that the tumor cells weakly expressed GLUT-1, Collagen IV, Ki-67 and p53. They were variably positive for CD34, S-100 protein and membrane epithelial antigen (EMA). Conclusions. The different types of nerve sheath cells observed in the present series reinforce the presence of heterogeneous population in NFs. The strong positivity for S-100 suggests that the lesions were more composed by S-100-positive Schwann cells than other cells. Besides, the high number of CD34-positive cells suggests that this marker can be useful for the differential diagnosis of NFs against PEN, traumatic neuromas and Schwannomas. Finally, the low immunostaining for p53 and Ki-67 may indicate that NFs massively composed by S-100-positive Schwann cells present low potential of aggressiveness and malignant transformation. [Campos, Marcia Sampaio] Universidade de Taubaté (Unitau), Dept Dent Oral Pathol Oral Med, BR-12020330 Taubate, SP, Brazil [Fontes, Alexandra; Marocchio, Luciana Sassa; Nunes, Fabio Daumas; Orsini Machado de Sousa, Suzana Cantanhede] Univ Sao Paulo, Sch Dent, Dept Stomatol Oral Pathol, Sao Paulo, Brazil |
| Databáze: | OpenAIRE |
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