Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant
Autor: | Dominique Gauguier, Angelique K. Salloum, Daniel E. Platt, Yasser Al-Sarraj, Antoine Abchee, Pierre Zalloua, Pascale Salameh, Francis Mouzaya, Marc Haber, Michella Ghassibe-Sabbagh, Hatem El-Shanti |
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Rok vydání: | 2015 |
Předmět: |
Male
medicine.medical_specialty endocrine system diseases Medicine (miscellaneous) 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Biology Logistic regression Lower risk Coffee Polymorphism Single Nucleotide Body Mass Index Cohort Studies 03 medical and health sciences chemistry.chemical_compound Sex Factors 0302 clinical medicine Cytochrome P-450 CYP1A2 Risk Factors Caffeine Internal medicine Environmental health medicine Humans Lebanon Alleles Genetic Association Studies Triglycerides Aged Genetic association Metabolic Syndrome Nutrition and Dietetics Cholesterol HDL nutritional and metabolic diseases Type 2 Diabetes Mellitus Cholesterol LDL Middle Aged medicine.disease Logistic Models Endocrinology Diabetes Mellitus Type 2 chemistry Hypertension Female Metabolic syndrome Body mass index Cohort study |
Zdroj: | Annals of Nutrition and Metabolism. 68:1-11 |
ISSN: | 1421-9697 0250-6807 |
Popis: | Cultural, dietary, and lifestyle factors are the main modulators of type 2 diabetes mellitus (T2DM) disease risk. Coffee is one of the most popular worldwide beverages, and recent epidemiological studies have showed that coffee consumption is associated with a lower risk of T2DM. This study investigates the impact of coffee intake on T2DM risk and assesses the effect of CYP variants with caffeine exposures on T2DM. Data from 7,607 study subjects were analyzed by logistic regression models, among whom 3,290 GWAS data were available for CYP variants association studies using Plink analysis. These data suggest a protective relationship for women, but not for men; however, the results were not statistically significant in this dataset and there is a significant interaction in favor of women regarding heavy coffee consumption. The interaction between male gender and heavy coffee consumption becomes significant, thereby tending to cancel the protective effect of coffee for males. CYP rs2470890 allele ‘C' increases the odds of T2DM by a factor of around 1.2 but decreases the odds of caffeine boosting T2DM of 1.7 by a factor of 0.77. rs2470890 showed an association with T2DM only when the interaction with coffee was considered, thereby setting an example of genetic activation by dietary changes associating with metabolic syndrome. |
Databáze: | OpenAIRE |
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