Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant

Autor: Dominique Gauguier, Angelique K. Salloum, Daniel E. Platt, Yasser Al-Sarraj, Antoine Abchee, Pierre Zalloua, Pascale Salameh, Francis Mouzaya, Marc Haber, Michella Ghassibe-Sabbagh, Hatem El-Shanti
Rok vydání: 2015
Předmět:
Male
medicine.medical_specialty
endocrine system diseases
Medicine (miscellaneous)
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Biology
Logistic regression
Lower risk
Coffee
Polymorphism
Single Nucleotide
Body Mass Index
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
Sex Factors
0302 clinical medicine
Cytochrome P-450 CYP1A2
Risk Factors
Caffeine
Internal medicine
Environmental health
medicine
Humans
Lebanon
Alleles
Genetic Association Studies
Triglycerides
Aged
Genetic association
Metabolic Syndrome
Nutrition and Dietetics
Cholesterol
HDL
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Cholesterol
LDL
Middle Aged
medicine.disease
Logistic Models
Endocrinology
Diabetes Mellitus
Type 2
chemistry
Hypertension
Female
Metabolic syndrome
Body mass index
Cohort study
Zdroj: Annals of Nutrition and Metabolism. 68:1-11
ISSN: 1421-9697
0250-6807
Popis: Cultural, dietary, and lifestyle factors are the main modulators of type 2 diabetes mellitus (T2DM) disease risk. Coffee is one of the most popular worldwide beverages, and recent epidemiological studies have showed that coffee consumption is associated with a lower risk of T2DM. This study investigates the impact of coffee intake on T2DM risk and assesses the effect of CYP variants with caffeine exposures on T2DM. Data from 7,607 study subjects were analyzed by logistic regression models, among whom 3,290 GWAS data were available for CYP variants association studies using Plink analysis. These data suggest a protective relationship for women, but not for men; however, the results were not statistically significant in this dataset and there is a significant interaction in favor of women regarding heavy coffee consumption. The interaction between male gender and heavy coffee consumption becomes significant, thereby tending to cancel the protective effect of coffee for males. CYP rs2470890 allele ‘C' increases the odds of T2DM by a factor of around 1.2 but decreases the odds of caffeine boosting T2DM of 1.7 by a factor of 0.77. rs2470890 showed an association with T2DM only when the interaction with coffee was considered, thereby setting an example of genetic activation by dietary changes associating with metabolic syndrome.
Databáze: OpenAIRE
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