Changing phase relationship of the stepping rhythm to neuronal oscillatory theta activity in the septo-hippocampal network of mice
| Autor: | Abhilasha Joshi, Peter Somogyi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Histology Stepping rhythm Short Communication Movement Hippocampus Sensory system Hippocampal formation Synchronization (alternating current) 03 medical and health sciences 0302 clinical medicine Rhythm Medial septum Neural Pathways Animals Theta Rhythm Phase relationship 030304 developmental biology Physics Theta oscillations Neurons 0303 health sciences Basal forebrain General Neuroscience Signal Processing Computer-Assisted Navigation Coupling (electronics) Mice Inbred C57BL Septal Nuclei Anatomy Neuroscience 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Brain Structure & Function |
| ISSN: | 1863-2661 1863-2653 |
| Popis: | Movement-related sensory and motor activity in the brain contributes to cognitive processes. We have observed that the frequency of stepping rhythm in head-fixed mice running on a jetball overlaps with the range of frequencies that characterize hippocampal rhythmic slow activity, including theta (~ 3 to 10 Hz). On average, step-cycle troughs (i.e. when the paw touches the ground) were weakly coupled to hippocampal theta oscillations. This weak coupling was sustained during a range of running speeds. In short temporal windows, step-cycle troughs were synchronous with hippocampal theta oscillatory cycle troughs, while during other periods they led or lagged behind theta cycles. Furthermore, simultaneously recorded theta rhythmic medial septal neurons in the basal forebrain were phase-coupled to both step-cycles and theta-cycles. We propose that the weak overall phase relationship of step-cycles with theta-cycles signifies a distinct mode of information processing. Transient synchronization of the step-cycle with theta may indicate the engagement of septo-hippocampal-entorhinal network with the current heading of the animal. Electronic supplementary material The online version of this article (10.1007/s00429-020-02031-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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