Morphology engineering of bacteria for bio-production
| Autor: | Xiao-Ran Jiang, Guo-Qiang Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Downstream processing Bacteria business.industry Polyhydroxyalkanoates Bioengineering Morphology (biology) High cell Biology biology.organism_classification Applied Microbiology and Biotechnology MreB Biotechnology 03 medical and health sciences Synthetic biology 030104 developmental biology Fermentation Synthetic Biology Biochemical engineering Bioprocess Cell shape business Cell Shape |
| Zdroj: | Biotechnology Advances. 34:435-440 |
| ISSN: | 0734-9750 |
| Popis: | The concept of "morphology engineering" is proposed here. There are many genes involved in maintaining the bacterial shapes. The manipulations of these genes allow us to change the bacterial shapes from rods to fibers or to small spheres or large spheres. The advantages of morphology engineered bacteria for bio-production including accelerated growth, high cell density, simplification of downstream separation, enlarged space for more inclusion body accumulation and reduction on the cost of bio-production, have recently started to be exploited. So far only a few shape related genes have been manipulated for bioprocess benefits, many more genes are to be exploited for various cell morphologies. The limits of bacterial lengths and diameters may depend on how we manipulate relevant genes. Over time, these limits can be broken to enhance bioprocess competitiveness including improvements on the effectiveness of up- and downstream bioprocessing. Morphology engineering is just starting to show its promises. |
| Databáze: | OpenAIRE |
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