Breast radiotherapy-related treatment outcomes in patients with or without germline mutations on multigene panel testing
Autor: | Michael C. Stauder, Diane Liu, George H. Perkins, David S. Lakomy, Scott J. Bright, Isabelle Bedrosian, Jennifer K. Litton, Shane R. Stecklein, Banu Arun, Karen E. Hoffman, Angelica M. Gutierrez Barrera, Eric A. Strom, Benjamin Smith, Wendy A. Woodward, Bhavana V. Chapman, Oluwafikayo O. Olamigoke, Yu Shen, Simona F. Shaitelman, Gabriel O. Sawakuchi |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment PALB2 Genes BRCA2 Breast Neoplasms Article Breast cancer Germline mutation Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Genetic Predisposition to Disease Stage (cooking) skin and connective tissue diseases CHEK2 Germ-Line Mutation Retrospective Studies Radiation business.industry BRCA1 Protein Cancer medicine.disease Radiation therapy Treatment Outcome Cohort Female Neoplasm Recurrence Local business |
Zdroj: | Int J Radiat Oncol Biol Phys |
Popis: | Purpose Multigene panel testing has increased the detection of germline mutations in patients with breast cancer. The implications of using radiation therapy (RT) to treat patients with pathogenic variant (PV) mutations are not well understood and have been studied mostly in women with only BRCA1 or BRCA2 PVs. We analyzed oncologic outcomes and toxicity after adjuvant RT in a contemporary, diverse cohort of patients with breast cancer who underwent genetic panel testing. Methods and Materials We retrospectively reviewed the records of 286 women with clinical stage I-III breast cancer diagnosed from 1995 to 2017 who underwent surgery, breast or chest wall RT with or without regional nodal irradiation, multigene panel testing, and evaluation at a large cancer center's genetic screening program. We evaluated rates of overall survival, locoregional recurrence, disease-specific death, and radiation-related toxicities in 3 groups: BRCA1/2 PV carriers, non-BRCA1/2 PV carriers, and patients without PV mutations. Results PVs were detected in 25.2% of the cohort (12.6% BRCA1/2 and 12.6% non-BRCA1/2). The most commonly detected non-BRCA1/2 mutated genes were ATM, CHEK2, PALB2, CDH1, TP53, and PTEN. The median follow-up time for the entire cohort was 4.4 years (95% confidence interval, 3.8-4.9 years). No differences were found in overall survival, locoregional recurrence, or disease-specific death between groups (P > .1 for all). Acute and late toxicities were comparable across groups. Conclusion Oncologic and toxicity outcomes after RT in women with PV germline mutations detected by multigene pane testing are similar to those in patients without detectable mutations, supporting the use of adjuvant RT as a standard of care when indicated. |
Databáze: | OpenAIRE |
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