Relationship between kidney function decline and initial risk factors for the progression of diabetic kidney disease: a retrospective analysis of 91 Japanese patients with type 2 diabetes
| Autor: | Yoshiharu Tokuyama, Atsuya Horie, Sumihiko Sato, Yukiko Hatanaka, Azuma Kanatsuka, Toshiharu Ishizuka |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Diabetic kidney business.industry Endocrinology Diabetes and Metabolism Clinical course Renal function 030209 endocrinology & metabolism Disease Type 2 diabetes 030204 cardiovascular system & hematology urologic and male genital diseases medicine.disease female genital diseases and pregnancy complications 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine medicine Retrospective analysis Original Article business |
| Zdroj: | Diabetology International. 7:432-439 |
| ISSN: | 2190-1686 2190-1678 |
| DOI: | 10.1007/s13340-016-0270-2 |
| Popis: | Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in Japan. The clinical course and factors related to the progression of DKD to ESRD are important issues when treating patients with DKD.Ninety-one type 2 diabetic patients with DKD that had progressed from chronic kidney disease (CKD) stages G1-3 on their initial clinical visit to ESRD were enrolled. The decline in the estimated glomerular filtration rate (eGFR) was analyzed and the initial clinical factors that influenced the decline rate were explored.There was a linear decline in eGFR before progression to ESRD, with a median annual decline rate (∆eGFR) of 9.2 mL/min/1.73 mIn addition to the common risk factors, initial eGFR, HDL-C, and TBil were identified as novel risk factors for ESRD. These risk factors may differ between patients with early and advanced stages of CKD. |
| Databáze: | OpenAIRE |
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