Prevalence of Self-reported Neurologic and Ocular Symptoms in Early Syphilis Cases
| Autor: | Rachel Amiya, Robbie Madera, Jaime K Walters, Sarah Kidd, Robin R. Hennessy, Craig Wilson, Laura A S Quilter, Elizabeth Torrone, Roxanne P. Kerani, Alex de Voux, Victoria M Pearson, James Matthias, Erin Davies |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Pediatrics medicine.medical_specialty 01 natural sciences Eye Infections Bacterial Ocular syphilis Neurosyphilis 03 medical and health sciences 0302 clinical medicine Prevalence medicine Humans Syphilis 030212 general & internal medicine 0101 mathematics Stage (cooking) Early syphilis medicine.diagnostic_test Lumbar puncture business.industry 010102 general mathematics medicine.disease Confidence interval Syphilis Serodiagnosis Infectious Diseases Self Report Complication business |
| Zdroj: | Clinical Infectious Diseases. 72:961-967 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciaa180 |
| Popis: | Background Neurosyphilis, a complication of syphilis, can occur at any stage of infection. Measuring the prevalence of neurosyphilis is challenging, and there are limited data on the prevalence of neurologic or ocular symptoms among patients with syphilis. We sought to describe the prevalence of neurologic and/or ocular symptoms among early syphilis (ES) cases and the clinical management of symptomatic cases enrolled in the STD Surveillance Network (SSuN) Neuro/Ocular Syphilis Surveillance project. Methods Persons diagnosed with ES were selected for interviews based on current health department protocols in 5 participating SSuN jurisdictions from November 2016 through October 2017. All interviewed ES cases were screened for self-reported neurologic and/or ocular symptoms. Additional clinical information on diagnostic testing and treatment for cases concerning for neurosyphilis/ocular syphilis was obtained from providers. Results Among 9123 patients with ES who were interviewed, 151 (1.7%; 95% confidence interval [CI], 1.4%–1.9%) reported ≥ 1 neurologic or ocular symptom. Of the 53 (35%) who underwent lumbar puncture, 22 (42%) had documented abnormal cerebrospinal fluid, of which 21 (95%) were treated for neurosyphilis/ocular syphilis. Among the remaining 98 symptomatic patients with no documented lumbar puncture (65%), 12 (12%) were treated for and/or clinically diagnosed with neurosyphilis/ocular syphilis. Conclusions We observed a low prevalence of self-reported neurologic and/or ocular symptoms in interviewed ES cases. Approximately one-third of ES cases who self-reported symptoms underwent further recommended diagnostic evaluation. Understanding barriers to appropriate clinical evaluation is important to ensuring appropriate management of patients with possible neurologic and/or ocular manifestations of syphilis. |
| Databáze: | OpenAIRE |
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