Silica-based nanocatalysts in the C[sbnd]C and C-heteroatom bond forming cascade reactions for the synthesis of biologically active heterocyclic scaffolds
| Autor: | E. Pérez Mayoral, Rosa M. Martín-Aranda, M.L. Rojas-Cervantes, Elena Soriano, Vanesa Calvino-Casilda |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España) |
| Rok vydání: | 2017 |
| Předmět: |
Chemical substance
010405 organic chemistry Chemistry Heteroatom Nanotechnology General Chemistry 010402 general chemistry 01 natural sciences Silica nanoparticles Catalysis Nanomaterial-based catalyst 0104 chemical sciences Multicomponent reactions Cascade reactions Molecule Hybrid materials Selectivity Science technology and society Hybrid material Heterocyclic rings Nanocatalysts |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The design and development of hybrid materials with application in catalysis science is an interesting researching field, especially in the chemical industry for fine chemicals production. The properties of nanostructured catalysts can be changed by tuning the interaction between the support and the active phases. Silica nanoparticles are very convenient solid supports for the synthesis of organic-inorganic hybrid nanocatalysts, endowing them of the required features to optimize activity and selectivity, stability and recyclability. In this review, we analyze the latest developments and give a perspective concerning the recent applications of silica-based nanocatalysts for the synthesis of heterocyclic scaffolds, biologically active, via cascade reactions. Heterocyclic rings often are the structural cores responsible of the biological activities in natural products and synthetic compounds. These systems are frequently synthesized by multicomponent reactions (MCRs), through cascade reactions. Such versatile catalytic systems have been successfully applied in a great variety of organic transformations for the synthesis of complex molecules and would play a key role in establishing new and more efficient sustainable technologies. This work has been supported by MICINN (project CTM2014-56668-R). VCC thanks UNED for her postdoctoral contract. |
| Databáze: | OpenAIRE |
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