Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids
| Autor: | M.G. Byers, Judith A. Brown, E. S. Cooper, L L Haley, Thomas B. Shows, Roger L. Eddy, A.P. Goggin |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Somatic cell
Genetic Linkage education Cell Electrophoresis Starch Gel Locus (genetics) Biology Hybrid Cells Aminopeptidases Mice Chromosome 18 Cricetinae Genetics medicine Animals Humans Chromosomes Human 4-5 Genetics (clinical) Phenotype Human genetics medicine.anatomical_structure Chromosome 4 Genes cardiovascular system Human genome |
| Zdroj: | Human genetics. 43(2) |
| ISSN: | 0340-6717 |
| Popis: | A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests that PEPS is composed of five or six identical subunits. Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids. Human genes coding for peptidases A, B, C, and D were assigned to chromosome 18, 12, 1, and 19, respectively, confirming previous assignments. These somatic cell genetic data demonstrate the independent genetic control of the several human peptidases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink