Combination of p53 and Ki67 as a Promising Predictor of Postoperative Recurrence of Meningioma
| Autor: | Takeo Goto, Atsufumi Nagahama, Kentaro Naito, Kenji Ohata, Takehiro Uda, Hiroki Morisako, Kosuke Nakajo, Tsutomu Ichinose, Masakazu Yashiro, Toshiyuki Kawashima |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Multivariate analysis Intracranial tumor Dura mater Meningioma Recurrence P53 status Biomarkers Tumor otorhinolaryngologic diseases Humans Medicine neoplasms Predictive marker business.industry General Medicine Prognosis medicine.disease nervous system diseases Ki-67 Antigen medicine.anatomical_structure Oncology Immunohistochemistry Female Tumor Suppressor Protein p53 business Immunostaining |
| Zdroj: | Anticancer Research. 41:203-210 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background Meningioma is a common intracranial tumor originating from arachnoid cap cells. Meningiomas are generally benign tumors curable by one-time resection. However, some meningiomas regrow and invade into the dura mater, and thus frequently require additional treatment. A useful marker to predict the regrowth of meningioma is desired. This study aimed to clarify the significance of p53 and Ki67 for postoperative recurrence of meningioma. Materials and methods The expression of p53 and Ki67 in 215 intracranial or intraspinal meningiomas was investigated by immunohistochemistry. Results Of the 215 meningiomas, 35 cases (16.3%) were p53-positive and 49 cases (22.8%) were Ki67-positive. Multivariate analysis revealed Ki67 and p53 status as being significantly correlated with recurrence. Positivity for either Ki67- or p53 was significantly associated with poor recurrence-free survival. Conclusion Combined p53 and Ki67 status might represent a useful independent predictive marker for recurrence of meningioma. |
| Databáze: | OpenAIRE |
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