Central nervous system injection of dynorphin-(1-13) overrides gastric satiety factors in sheep
| Autor: | J. A. Paterson, Clifton A. Baile, J. L. Miner, Mary Anne Della-Fera, B. D. Coleman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Narcotics
medicine.medical_specialty Rumen Physiology Central nervous system Endogeny Dynorphin Acetates Satiation Biology Stimulus (physiology) Dynorphins Satiety Response Cerebral Ventricles Injections Eating Physiology (medical) Internal medicine medicine Animals Ingestion Opioid peptide Injections Intraventricular Meal Stomach Fatty Acids Volatile Peptide Fragments medicine.anatomical_structure Endocrinology Female Propionates |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.1990.258.4.r946 |
| Popis: | Signals from the gastrointestinal (GI) tract, arising during ingestion and digestion of food, are important in the termination of feeding. This study was carried out to determine whether the satiety triggered by specific GI stimuli in sheep could be reversed by central nervous system (CNS) administration of dynorphin, a putative endogenous kappa-opiate receptor ligand, which has been shown to be a potent feed-intake stimulant in many species. Rumen distension and increased intraruminal concentration of propionic acid (an energy substrate produced during fermentation in the rumen) both significantly decreased feed intake in fasted sheep. When either of these stimuli were combined with continuous 60-min lateral cerebroventricular injection of [D-Ala2]dynorphin A-(1-13) (0.32 nmol/min), feed intake returned to control levels. Increasing feed intake in food-producing animals is an important way of improving production efficiency. The findings of these experiments illustrate how manipulation of a CNS opioid system can modify the effects of feed intake-limiting factors generated by ingestion of a meal, thereby promoting greater feed intake. |
| Databáze: | OpenAIRE |
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