Precision nutrition and cancer relapse prevention: A systematic literature review

Autor: Guillermo Reglero, Clara Reglero
Přispěvatelé: Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid, Reglero, Clara [0000-0002-3232-5163], Reglero, Guillermo [0000-0002-7730-3486], Reglero, Clara, Reglero, Guillermo
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Oncology
Lung Neoplasms
Cancer relapse
bioactive phytochemical foodstuffs
medicine.medical_treatment
Phytochemicals
Review
Disease
Metastasis
Prostate cancer
0302 clinical medicine
Neoplasms
Precision Medicine
precision nutrition
Lung
Nutrition and Dietetics
prostate
Leukemia
leukemia
Prostate
Systematic review
030220 oncology & carcinogenesis
Colonic Neoplasms
Female
Nutrition Therapy
Adjuvant
lcsh:Nutrition. Foods and food supply
medicine.medical_specialty
Colon
Breast Neoplasms
lcsh:TX341-641
lung
03 medical and health sciences
Internal medicine
medicine
Humans
cancer relapse
breast
colon
business.industry
Prostatic Neoplasms
Cancer
Precision nutrition
medicine.disease
Precision medicine
030104 developmental biology
Tumor progression
Neoplasm Recurrence
Local
Bioactive phytochemical foodstuffs
business
Food Science
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nutrients, Vol 11, Iss 11, p 2799 (2019)
Nutrients
Popis: This article belongs to the Special Issue Dietary Patterns, Dietary Indices for Colorectal Cancer, Mortality and the Related Disease.
Cancer mortality rates are undergoing a global downward trend; however, metastasis and relapse after surgery and adjuvant treatments still correlate with poor prognosis and represent the most significant challenges in the treatment of this disease. Advances in genomics, metabolomics, and proteomics are improving our understanding regarding cancer metabolic diversity, resulting in detailed classifications of tumors and raising the effectiveness of precision medicine. Likewise, the growing knowledge of interactions between nutrients and the expression of certain genes could lead to cancer therapies based on precision nutrition strategies. This review aims to identify the recent advances in the knowledge of the mechanistic role of bioactive phytochemicals in foodstuffs in tumor progression, metastasis, and chemo-resistance in order to assess their potential use in precision nutrition therapies targeting relapse in lung, breast, colon, and prostate cancer, and leukemia. A considerable number of bioactive phytochemicals in foodstuffs were identified in the literature with proven effects modulating tumor growth, progression, and metastasis. In addition, the use of foodstuffs in cancer, and specifically in relapse therapies, is being reinforced by the development of different formulations that significantly increase the therapeutic efficiency of these products. This can open the possibility for testing combinations of bioactive phytochemicals with cancer relapse treatments as a potential prevention strategy.
This research is part of the work plan of Project AGL2016-76736-C3 supported by the Spanish Ministerio de Ciencia, Innovación y Universidades; Project P2018/BAA-4343-ALIBIRD2020-CM supported by the Regional Government of Comunidad de Madrid (V PRICYT).
Databáze: OpenAIRE
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