CircPUM1 promotes hepatocellular carcinoma progression through the miR‐1208/MAP3K2 axis
| Autor: | Tao Zhu, Yaqiong Zhang, Xiaoyu Wu, Minqi Zhu, Yingjie Dai, Jin Yu, Jie Zhu, Dongguo Wang, Weidong Lin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Carcinoma Hepatocellular Common disease Blotting Western Mice Nude MAP Kinase Kinase Kinase 2 MAP3K2 03 medical and health sciences 0302 clinical medicine In vivo medicine Animals Effective treatment miR‐1208 neoplasms Mice Inbred BALB C Oncogene business.industry Liver Neoplasms RNA-Binding Proteins hepatocellular carcinoma Cell Biology medicine.disease digestive system diseases In vitro Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Molecular Medicine Original Article circPUM1 business |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| DOI: | 10.1111/jcmm.15998 |
| Popis: | Hepatocellular carcinoma (HCC) is a common disease with a significant mortality, and there is no effective treatment for advanced patients. Growing evidence indicates that circRNAs are closely related to HCC progression, may be used as biomarkers and targets for the diagnosis and treatment of HCC. Recent researches have shown that circPUM1 may play an oncogene role in a variety of human cancers, but its role in HCC development has not been reported. Our study found that circPUM1 could promote the proliferation, migration and invasion of HCC cells in vitro. In addition, in vivo studies showed that circPUM1 could increase the development of HCC tumours and regulate the expression of EMT‐related proteins. Furthermore, we demonstrated that circPUM1 could promote the development of HCC by up‐regulating the expression of MAP3K2 via sponging miR‐1208. Our study suggested that circPUM1 may be a potential therapeutic target for HCC. |
| Databáze: | OpenAIRE |
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