Utility of Kyoto Classification of Gastritis in subjects with a high-negative titer of anti-Helicobacter pylori antibody during a medical check-up
| Autor: | Shusei Fukunaga, Yasuaki Nagami, Akinobu Nakata, Yasuhiro Fujiwara, Tetsuya Tanigawa, Norifumi Kawada, Toshio Watanabe, Fumio Tanaka, Yuji Nadatani, Koji Otani, Shinya Fukumoto, Tatsuo Kimura, Koichi Taira, Shuhei Hosomi, Noriko Kamata, Satoshi Kosaka, Yuji Matsumoto |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Clinical Biochemistry Medicine (miscellaneous) Kyoto Classification of Gastritis Logistic regression Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine medical check-up 030109 nutrition & dietetics Nutrition and Dietetics Helicobacter pylori high-negative titer Receiver operating characteristic biology business.industry Odds ratio bacterial infections and mycoses biology.organism_classification Confidence interval Titer anti-H. pylori antibody biology.protein Original Article 030211 gastroenterology & hepatology Gastritis medicine.symptom Antibody business |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.20-21 |
| Popis: | Subjects with a high-negative titer (3–9.9 U/ml) of serum anti-Helicobacter pylori (H. pylori) antibody represent a heterogeneous group of currently H. pylori-infected, H. pylori-uninfected, and previously H. pylori-infected cases. We investigated the characteristics of subjects with a high-negative titer during a medical check-up and the utility of H. pylori infection score, the sum of scores of endoscopic findings based on the Kyoto Classification of Gastritis, for diagnosing H. pylori infection. Subjects with 13C-urea breath test-positive or H. pylori stool antigen test-positive were diagnosed as currently H. pylori-infected. Although around half of subjects with a high-negative titer were after eradication therapy (48.6%), currently H. pylori-infected were considerably confirmed (11.7%). H. pylori infection score showed a high value of area under the receiver operating characteristic curve [0.92; 95% confidence interval (CI), 0.84–1.00] with the most suitable cut-off value of 1.0 (sensitivity: 0.92; specificity: 0.90). Multivariate logistic regression analysis revealed that H. pylori infection score was an independent factor associated with increased prevalence of H. pylori infection (odds ratio, 9.53; 95% CI, 2.64–34.40; p |
| Databáze: | OpenAIRE |
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