Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study
| Autor: | Barbara H. Hanusa, B. A. Cohlan, Robyn Baker, Barbara Medoff-Cooper, Debra L. Bogen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty Birth weight law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Weight loss 030225 pediatrics Humans Medicine 030212 general & internal medicine Child Research Articles Retrospective Studies business.industry Weight change Infant Newborn Infant Gestational age General Medicine Length of Stay Infant formula Hospitalists Pediatrics Perinatology and Child Health medicine.symptom business Neonatal Abstinence Syndrome Weight gain Methadone medicine.drug |
| Zdroj: | Hospital Pediatrics. 8:7-14 |
| ISSN: | 2154-1671 2154-1663 |
| DOI: | 10.1542/hpeds.2017-0114 |
| Popis: | BACKGROUND: Newborns who are prenatally exposed to methadone are at risk for neonatal abstinence syndrome and the associated excess weight loss and poor weight gain. This pilot feasibility study aimed to evaluate early caloric enhancement on weight patterns among infants born to women receiving methadone maintenance therapy while pregnant. METHODS: In this double-blind pilot feasibility study, we randomly assigned infants with fetal methadone exposure to 24 or 20 kcal/oz formula from days 3 to 21. Randomization was stratified by any breastfeeding, sex of the infant, and gestational age. Eligible infants were ≥35 weeks’ gestation and weighed ≥2200 g. Outcomes were days to weight nadir, maximum percent weight loss, days to birth weight, percentage weight change per day, and feasibility. RESULTS: A total of 49 infants were randomly assigned (22 to standard- and 27 to high-calorie formula); groups had comparable demographic characteristics. Main outcomes comparing standard- to high-calorie formula groups were not significant (days to weight nadir, 5.0 vs 4.4 days; P = .20; maximum percent weight loss, −9.4% vs −8.6%; P = .15; days to birth weight, 14.7 vs 13.6 days; P = .07); however, in longitudinal analyses (days 4 to 21), the high-calorie group had a higher percent weight gained per day compared with the standard-calorie group (P CONCLUSIONS: Study findings suggest that early initiation of high-calorie formula for infants with prenatal methadone exposure may be beneficial for weight gain; evaluation in a larger study is warranted. |
| Databáze: | OpenAIRE |
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