Gender‐Specific Risk Factors for Peripheral Artery Disease in a Voluntary Screening Population

Autor: Michael S. Conte, Jade S. Hiramoto, Ronit Katz, Steven Weisman
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Volition
Health Knowledge
Attitudes
Practice
Cross-sectional study
Health Behavior
Coronary artery disease
Interquartile range
Risk Factors
Surveys and Questionnaires
Prevalence
Mass Screening
Community Health Services
Original Research
education.field_of_study
biology
Middle Aged
C‐reactive protein
C-Reactive Protein
risk factor
gender differences
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Population
peripheral artery disease
Risk Assessment
Peripheral Arterial Disease
Sex Factors
Predictive Value of Tests
Internal medicine
Diabetes mellitus
medicine
Humans
Ankle Brachial Index
cardiovascular diseases
Risk factor
education
Mass screening
Aged
business.industry
C-reactive protein
Health Status Disparities
medicine.disease
United States
Cross-Sectional Studies
Physical therapy
biology.protein
business
Biomarkers
Health Services and Outcomes Research
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
Popis: Background Women have high rates of peripheral artery disease ( PAD ) despite fewer cardiovascular disease ( CVD ) risk factors, compared to men. We sought to determine the gender‐specific prevalence of low ankle brachial index ( ABI ) and the relationship to C‐reactive protein ( CRP ) levels and CVD risk factors in the Life Line Screening population. Methods and Results Between April 2005 and August 2011, 133 750 women and 71 996 men had ABI and CRP measured at a Life Line Screening Center. Women were slightly older than men, whereas men were more likely to be current smokers, have diabetes mellitus ( DM ), and coronary artery disease ( CAD ) ( P ABI ≤1.0, compared to men (26.6% versus 14.4%, respectively; P ABI ≤0.9 (4.1% women versus 2.6% men; P CRP levels (1.94 mg/L; interquartile range [ IQR], 0.89, 4.44 mg/L), compared to men (1.35 mg/L; IQR, 0.73, 2.80 mg/L; P ABI ≤0.9, including older age, black race, smoking, DM , hypertension, hypercholesterolemia, CAD , and elevated CRP levels. In an adjusted model, there were significant interactions between gender and age ( P CRP ( P CAD ( P =0.03), and DM ( P =0.06) with ABI as the outcome. The associations between age, CRP , CAD , and DM with ABI ≤0.9 were stronger in men than in women. Conclusions Women participating in the Life Line Screening had higher CRP levels and a higher prevalence of PAD, compared to men. Neither higher CRP levels nor conventional CVD risk factors explained the excess prevalence of PAD in women.
Databáze: OpenAIRE
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