Protective effect of crocin against the declining of high spatial frequency-based visual performance in mice
| Autor: | Ping-Hsun Wang, Meng-Chih Lee, Shih-Liang Yang, Jia-Lain Wu, Yun-Ping Huang, Jyh-Cheng Liou, Bo-Yie Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Visual acuity
genetic structures Vision Visual contrast sensitivity function ved/biology.organism_classification_rank.species Medicine (miscellaneous) Pharmacology Retina Crocin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Crocus sativus medicine TX341-641 Photoreceptor Nutrition and Dietetics biology Nutrition. Foods and food supply ved/biology Müller cell Retinal biology.organism_classification eye diseases medicine.anatomical_structure chemistry Gliosis Gardenia 030221 ophthalmology & optometry Reflex sense organs medicine.symptom 030217 neurology & neurosurgery Food Science |
| Zdroj: | Journal of Functional Foods, Vol 49, Iss, Pp 314-323 (2018) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2018.08.031 |
| Popis: | The high spatial frequency-based vision was primary on cone rich macular vision. Crocin is a major bioactive constituent of saffron (Crocus sativus L. flowers) and gardenia fruit (Gardenia spp.), which has powerful antioxidant capacities in retina. The study aim to evaluate the influence of crocin on visual performance in light-damaged mouse retinas in vivo. The visual acuity (VA), and visual contrast sensitivity function (VCSF) were measured by the behavioral optomotor reflex method. The histological changes of retinas were monitored. Both VA and VCSF declines, and that accompanied by Muller cell hypertrophic gliosis and cone cellular damage were detected in the vehicle groups. Prophylactic crocin treated groups improved VA and VCSF on sensitive to high spatial frequency, protected retinal integrity and Muller cells, and modulated the cellular function of cone. This study provides the potential use of crocin to ameliorate the visual performance due to its anti-photodamage and cytoprotective effects. |
| Databáze: | OpenAIRE |
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