Multimodal assessment of sleep in men and women during treatment for opioid use disorder
| Autor: | David H. Epstein, Karran A. Phillips, Patrick H. Finan, Chung Jung Mun, William J. Kowalczyk, Kenzie L. Preston, Daniel Agage, Michael T. Smith |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Sleep Wake Disorders medicine.medical_specialty Ecological Momentary Assessment Monitoring Ambulatory Toxicology Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Opiate Substitution Treatment Humans Medicine Pharmacology (medical) 030212 general & internal medicine Pharmacology Sleep disorder business.industry Electroencephalography Opioid use disorder Middle Aged Opioid-Related Disorders medicine.disease Sleep in non-human animals Buprenorphine Analgesics Opioid Psychiatry and Mental health Ambulatory Female Sleep diary Smartphone Sleep onset business Methadone 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Drug Alcohol Depend |
| ISSN: | 0376-8716 |
| Popis: | Background Sleep disturbance is common in patients with opioid use disorder (OUD) receiving medication for addiction treatment. Differences between patients on the two primary agonist medications—methadone and buprenorphine—are not well understood. Methods In patients receiving either methadone or buprenorphine treatment for OUD, we examined sleep continuity and architecture using ambulatory monitoring to gather both an objective measure (daily sleep EEG; M = 5.76 days, SD = 1.46) and a subjective measure (daily sleep diary; M = 54.10 days, SD = 25.10) of sleep. Results Patients treated with buprenorphine versus methadone did not differ on any measure of sleep continuity or architecture. Women had longer EEG-derived total sleep time than men (d = -0.68, 95 % CI -1.32 to -0.09), along with lower %N2 (d = 0.94, 95 % CI 0.34–1.64) and greater %N3 (d = -0.94, 95 % CI -1.61 to -0.32). Self-reported sleep differed from EEG-derived estimates: wake after sleep onset was greater by EEG than by diary (d = 2.58, 95 % CI 1.74–3.63), and total sleep time and sleep efficiency were lower by EEG than by diary (d for sleep time = 2.93, 95 % CI 2.06–4.14; d for efficiency = 1.69, 95 % CI 0.98–2.49). Conclusions Patients treated with buprenorphine or methadone did not substantively differ in ambulatory measures of sleep. With both medications, there was a discrepancy between objective and subjective sleep measures. Further confirmatory evidence would inform the development of sleep-related recommendations for OUD patients undergoing agonist treatment. |
| Databáze: | OpenAIRE |
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