Risk of Hematological Malignancies among Chernobyl Liquidators
| Autor: | Sergei V. Illichev, Juozas Kurtinaitis, Vladimir Gapanovich, Natalia Shchukina, Phillipe Hubert, Ivan Golovanov, André Bouville, Anne-Sophie Evrard, Ausrele Kesminiene, Mare Tekkel, Svetlana E. Khait, Vanessa Tenet, Lynn R. Anspaugh, Marat Maksyoutov, Vadim V. Chumak, Tatyana I. Tserakhovich, Irina V Malakhova, Elisabeth Cardis, Sergei Chekin, Viktor P. Kryuchkov, Evaldas Maceika, Aleksandr Tsykalo, Vladimir Drozdovitch, Aleksandr R. Tukov, Semion Polyakov, V.K. Ivanov, Anatoly K. Mirkhaidarov, Aivars Stengrevics |
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| Přispěvatelé: | Centre internationale de recherche sur le cancer, Medical Radiological Research Centre, Russian Academy of Medical Sciences, Republican Scientific and Practical Center for Medical Technologies, Informatization, Administration and Managemetn of Health, Institute of Oncology, Latvian Centre of Oncology, National Institute for Health Development, Department of Radiology, University of Utah, U.S. National Cancer Institute, National Institutes of Health, Scientific Centre for Radiation Medecine, Research Institute of Haematology and Blood Transfusion, Institute of Biophysics, Institut National de l'Environnement Industriel et des Risques (INERIS), ENERGOATOM, National Nuclear Energy Genertion Company, Institute of Physics, Czech Academy of Sciences [Prague] (CAS), Republican Scientific Centre of Radiation Medecine and Human Ecology, Chernobyl Nuclear Power Plant, Department of Dose Reconstruction |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Neoplasms Radiation-Induced Biophysics Radiation Dosage Chernobyl Nuclear Accident Risk Assessment Sensitivity and Specificity Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Occupational Exposure Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Environmental Restoration and Remediation Radiation business.industry Uncertainty Case-control study Middle Aged medicine.disease Confidence interval 3. Good health Lymphoma Leukemia medicine.anatomical_structure Case-Control Studies Hematologic Neoplasms 030220 oncology & carcinogenesis Relative risk [SDE]Environmental Sciences Bone marrow Risk assessment business Nuclear medicine |
| Zdroj: | Radiation Research Radiation Research, Radiation Research Society, 2008, 170 (6), pp.721-735. ⟨10.1667/RR1231.1⟩ |
| ISSN: | 1938-5404 0033-7587 |
| Popis: | International audience; A case-control study of hematological malignancies was conducted among Chernobyl liquidators (accident recovery workers) from Belarus, Russia and Baltic countries to assess the effect of low- to medium-dose protracted radiation exposures on the relative risk of these diseases. The study was nested within cohorts of liquidators who had worked around the Chernobyl plant in 1986-1987. A total of 117 cases [69 leukemia, 34 non-Hodgkin lymphoma (NHL) and 14 other malignancies of lymphoid and hematopoietic tissue] and 481 matched controls were included in the study. Individual dose to the bone marrow and uncertainties were estimated for each subject. The main analyses were restricted to 70 cases (40 leukemia, 20 NHL and 10 other) and their 287 matched controls with reliable information on work in the Chernobyl area. Most subjects received very low doses (median 13 mGy). For all diagnoses combined, a significantly elevated OR was seen at doses of 200 mGy and above. The excess relative risk (ERR) per 100 mGy was 0.60 [90% confidence interval (CI) _0.02, 2.35]. The corresponding estimate for leukemia excluding chronic lymphoid leukemia (CLL) was 0.50 (90% CI _0.38, 5.7). It is slightly higher than but statistically compatible with those estimated from A-bomb survivors and recent low-doserate studies. Although sensitivity analyses showed generally similar results, we cannot rule out the possibility that biases and uncertainties could have led to over- or underestimation of the risk in this study. |
| Databáze: | OpenAIRE |
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