Role of mitochondrial dysfunction in hyperglycaemia-induced coronary microvascular dysfunction: Protective role of resveratrol
| Autor: | Philip J. Berger, Mandar S. Joshi, Duncan Horlock, Jaye Chin-Dusting, David M. Kaye, David R. Williams, Ann-Maree Jefferis, Thilini Samarasinghe, Karen L. Andrews |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Time Factors Diabetic rat Endocrinology Diabetes and Metabolism Coronary Artery Disease Mitochondrion Resveratrol medicine.disease_cause Cardiac dysfunction Diabetes Mellitus Experimental Rats Sprague-Dawley chemistry.chemical_compound Cell Movement Diabetes mellitus Internal medicine Coronary Circulation Stilbenes Internal Medicine medicine Animals Humans Endothelial dysfunction Diabetic Vascular Complications Cells Cultured Cell Proliferation business.industry Microcirculation Endothelial Cells Isolated Heart Preparation medicine.disease Coronary Vessels Myocardial Contraction Mitochondria Vasodilation Endocrinology chemistry Microvessels Cardiology and Cardiovascular Medicine business Oxidative stress Diabetic Angiopathies |
| Zdroj: | Diabetesvascular disease research. 12(3) |
| ISSN: | 1752-8984 |
| Popis: | Microvascular complications are now recognized to play a major role in diabetic complications, and understanding the mechanisms is critical. Endothelial dysfunction occurs early in the course of the development of complications; the precise mechanisms remain poorly understood. Mitochondrial dysfunction may occur in a diabetic rat heart and may act as a source of the oxidative stress. However, the role of endothelial cell-specific mitochondrial dysfunction in diabetic vascular complications is poorly studied. Here, we studied the role of diabetes-induced abnormal endothelial mitochondrial function and the resultant endothelial dysfunction. Understanding the role of endothelial mitochondrial dysfunction in diabetic vasculature is critical in order to develop new therapies. We demonstrate that hyperglycaemia leads to mitochondrial dysfunction in microvascular endothelial cells, and that mitochondrial inhibition induces endothelial dysfunction. Additionally, we show that resveratrol acts as a protective agent; resveratrol-mediated mitochondrial protection may be used to prevent long-term diabetic cardiovascular complications. |
| Databáze: | OpenAIRE |
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