Antiretroviral therapy and HIV-associated cancers: Antiangiogenic effect of efavirenz on chick chorioallantoic membrane
| Autor: | Margot J. Hosie, Clement Penny, Rosie Thecla McNeil |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Drug animal structures Efavirenz Angiogenesis media_common.quotation_subject Fowl Pharmaceutical Science Pharmacology Chick chorioallantoic membrane 03 medical and health sciences chemistry.chemical_compound immune system diseases In vivo medicine Pharmacology (medical) media_common biology business.industry virus diseases biology.organism_classification Efavirenz HIV Cancers Angiogenesis Chick chorioallantoic membrane Thalidomide Regimen 030104 developmental biology chemistry business medicine.drug |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol 16, No 11 (2017); 2741-2747 |
| ISSN: | 1596-5996 1596-9827 |
| Popis: | Purpose: To investigate the anti-angiogenic effect of efavirenz in chick chorioallantoic membrane (CAM). Methods: Fertile eggs of the domestic fowl (Gallus gallus, variant Domesticus) were used as the in vivo vascular test environment. Experimental groups were VEGF, thalidomide (negative control), efavirenz (test drug), control 1 (treated with diluent) and control 2 (no treatment). CAM photographs were taken using a microscope camera. CAM blood vessels were scored as either “present” or “absent”. Results: There was association between treatment drugs and growth of CAM blood vessels (p < 0.05) as follows: control 1 – 100 %, control 2 – 67 %, VEGF - 83 %, thalidomide - 17 %, and efavirenz - 0 % (n = 30). Although efavirenz had absolute anti-angiogenicity and presented as a potential anti-cancer drug, there was no significant difference between the anti-angiogenicity of efavirenz (100 %) and thalidomide (83 %) (F = 1.000, p = 0.341). Conclusion : Being a first-line drug in both HAART and combination treatment of HIV-1, efavirenz may be responsible for spontaneous resolution of secondary cancers in HIV-infected patients on HAART regimen. Keywords : Efavirenz, HIV, Cancers, Angiogenesis, Chick chorioallantoic membrane |
| Databáze: | OpenAIRE |
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