Graphene Oxide–PEG–Protocatechuic Acid Nanocomposite Formulation with Improved Anticancer Properties
| Autor: | Kalaivani Buskaran, Mohd Zobir Hussein, Bullo Saifullah, Rabia Baby Shaikh, Farahnaz Barahuie, Mohd Aris Mohd Moklas, Sharida Fakurazi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
General Chemical Engineering
02 engineering and technology Pharmacology 010402 general chemistry 01 natural sciences Protocatechuic acid Article lcsh:Chemistry liver cancer chemistry.chemical_compound In vivo PEG ratio medicine cancer General Materials Science Cancer 021001 nanoscience & nanotechnology medicine.disease PEG In vitro 0104 chemical sciences chemistry lcsh:QD1-999 colon cancer protocatechuic acid Drug delivery Cancer cell drug delivery graphene oxide Nanocarriers 0210 nano-technology |
| Zdroj: | Nanomaterials Volume 8 Issue 10 Nanomaterials, Vol 8, Iss 10, p 820 (2018) |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano8100820 |
| Popis: | The treatment of cancer through chemotherapy is limited by its toxicity to healthy tissues and organs, and its inability to target the cancer site. In this study, we have designed an anticancer nanocomposite delivery system for protocatechuic acid (PCA) using graphene oxide&ndash polyethylene glycol as the nanocarrier, and coated with folic acid (GO&ndash PEG&ndash PCA&ndash FA) for targeting the cancer cells. The designed anticancer delivery system was found to show much better anticancer activity than the free drug PCA against liver cancer HEP-G2 cells and human colon cancer HT-29 cells at same time, it was found to be less toxic to normal fibroblast 3T3 cells. The folate-coated anticancer delivery system was found to show better activity then the free drug and the uncoated anticancer delivery system. The in vitro release of the PCA was found to be sustained in human physiological pHs, i.e., blood pH 7.4 and intracellular lysosomal pH 4.8. These in vitro findings are highly encouraging for further in vivo evaluation studies. |
| Databáze: | OpenAIRE |
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