Sulfonylureas: do we need to introspect safety again?
| Autor: | Devindra Sehra, Sudhish Sehra, Shiv T Sehra |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class MEDLINE Pharmacology Katp channels medicine Animals Humans Hypoglycemic Agents Pharmacology (medical) Intensive care medicine Prescribed medications Adverse effect Randomized Controlled Trials as Topic business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Sulfonylurea Clinical trial Search terms Sulfonylurea Compounds Diabetes Mellitus Type 2 business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Expert opinion on drug safety. 10(6) |
| ISSN: | 1744-764X |
| Popis: | Sulfonylureas (SUs) are the most commonly prescribed medications for type 2 diabetes mellitus worldwide. Differences among SUs for kinetic and adenosine triphosphate sensitive potassium (KATP) channels selectivity and consequential extrapancreatic effects, although recognized in literature, are not considered by treatment guidelines.The roles of SUs in various system-related adverse effects have not been well understood. Inconsistencies in the literature and lack of clinical trials assessing the long-term effects of monotherapy or combination therapy with SUs add to the concern. This review provides insights in issues concerning safety of SUs based on literature published between 1980 and 2011. A comprehensive search was carried out on PubMed, Embase and Cochrane databases using the search terms: sulfonylureas, sulfonylureas and KATP channels, sulfonylureas and cardiovascular (CV) effects and sulfonylureas side effects.SUs have been linked to CV events, growth hormone (GH) disorder, malignancy, weight gain, erectile dysfunction and central nervous system (CNS) adverse effects. These adverse effects generally get masked as they are thought to be related to diabetes per se. The current article will allow the fraternity to ponder and undertake further research on the ill effects of largely prescribed antidiabetic medication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|