Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations
| Autor: | Arthur Shulkes, Elizabeth Delbridge, Supornpim Chearskul, Joseph Proietto, Adamandia Kriketos |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Hunger media_common.quotation_subject Peptide Hormones Medicine (miscellaneous) Ketone Bodies Fatty Acids Nonesterified Satiation Body Mass Index Eating Weight loss Internal medicine Weight Loss medicine Humans Insulin Nutritional Physiological Phenomena Obesity Cholecystokinin media_common Nutrition and Dietetics Anthropometry Chemistry digestive oral and skin physiology Metabolic disorder Appetite Ketosis Middle Aged medicine.disease Postprandial Period Adaptation Physiological Gastrointestinal Tract Postprandial Endocrinology Ketone bodies medicine.symptom Signal Transduction |
| Zdroj: | The American journal of clinical nutrition. 87(5) |
| ISSN: | 1938-3207 |
| Popis: | Background Weight regain after weight loss may not be due primarily to voluntary return to social habits but may be explained by changes in peripheral hormonal signals activating hunger and encouraging feeding behavior. Objective The objective of this study was to investigate physiologic adaptations to weight loss that may encourage weight regain. Design The study had a within-subject repeated-measure design [12 healthy, obese men, 33-64 y, body mass index (in kg/m(2)) 30-46] and was a clinical intervention investigation of circulating metabolites and hunger-satiety responses before and after weight loss. Measures included anthropometry (bioelectrical impedance, body weight, and waist circumference), concentrations of circulating hormones and metabolites [ketone bodies, free fatty acids (FFAs), insulin, leptin, glucose, and cholecystokinin (CCK)], and measures of hunger and satiety at baseline, 8 wk after weight loss with a very-low-energy diet, and 1 wk after weight maintenance. Results Weight loss led to a reduction in postprandial CCK secretion (P = 0.016). However, when subjects were ketotic (elevated circulating beta-hydroxybutyrate concentrations), CCK secretion was sustained at concentrations before weight loss. After weight loss, there were reduced postprandial FFA concentrations (P = 0.0005). The presence of ketosis sustained FFA to concentrations before weight loss (P = 0.60). Conclusion Rapid weight loss of approximately 10% of initial body weight results in a reduction in postprandial CCK and FFA concentrations. |
| Databáze: | OpenAIRE |
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