Verbal recall and recognition in twins discordant for schizophrenia
| Autor: | Matti O. Huttunen, Annamari Tuulio-Henriksson, Tyrone D. Cannon, Markku Koskenvuo, David C. Glahn, Peter Bachman, Sebastian Therman, Jaakko Kaprio, Tiia Pirkola, Marja Hietanen, Jouko Lönnqvist, Theo G.M. van Erp |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Audiology Verbal learning Hippocampus behavioral disciplines and activities Article Developmental psychology 03 medical and health sciences 0302 clinical medicine Diseases in Twins Twins Dizygotic medicine Humans Finland Biological Psychiatry Recognition memory Psychiatric Status Rating Scales Memory Disorders Language Tests California Verbal Learning Test Recall Recognition Psychology Twins Monozygotic Verbal Learning medicine.disease Control Groups 030227 psychiatry Psychiatry and Mental health Phenotype Free recall Psychotic Disorders Schizophrenia Mental Recall Female Schizophrenic Psychology Verbal memory Psychology 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry Research. 159:271-280 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2007.03.003 |
| Popis: | The nature, neural underpinnings, and etiology of deficits in verbal declarative memory in patients with schizophrenia remain unclear. To examine the contributions of genes and environment to verbal recall and recognition performance in this disorder, the California Verbal Learning Test was administered to a large population-based Finnish twin sample, which included schizophrenic and schizoaffective patients, their non-ill monozygotic (MZ) and dizygotic (DZ) co-twins, and healthy control twins. Compared with controls, patients and their co-twins showed relatively greater performance deficits on free recall compared with recognition. Intra-pair differences between patients and their non-ill co-twins in hippocampal volume and memory performance were highly positively correlated. These findings are consistent with the view that genetic influences are associated with reduced verbal recall in schizophrenia, but that non-genetic influences further compromise these abnormalities in patients who manifest the full-blown schizophrenia phenotype, with this additional degree of disease-related declarative memory deficit mediated in part by hippocampal pathology. |
| Databáze: | OpenAIRE |
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