Analysis for interaction between interleukin-35 genes polymorphisms and risk factors on susceptibility to coronary heart disease in the Chinese Han population

Autor: Jin-Yan Huang, Kui Wang, Ying-Xue Liu, Yu-Feng Zhu, Hu Li
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
medicine.medical_specialty
China
lcsh:Diseases of the circulatory (Cardiovascular) system
Interaction
Single-nucleotide polymorphism
Coronary Disease
030204 cardiovascular system & hematology
Logistic regression
Polymorphism
Single Nucleotide
Risk Assessment
Interleukin-12 Subunit p35
Minor Histocompatibility Antigens
03 medical and health sciences
0302 clinical medicine
Asian People
Polymorphism (computer science)
Risk Factors
Internal medicine
Genotype
medicine
Humans
Genetic Predisposition to Disease
Allele
Genetic Association Studies
030304 developmental biology
Angiology
Aged
0303 health sciences
Interleukin-35
Multifactor dimensionality reduction
business.industry
Interleukins
Smoking
Single nucleotide polymorphisms
Middle Aged
Cardiac surgery
Coronary heart disease
Phenotype
lcsh:RC666-701
Case-Control Studies
Female
Gene-Environment Interaction
Cardiology and Cardiovascular Medicine
business
Research Article
Zdroj: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
BMC Cardiovascular Disorders
ISSN: 1471-2261
Popis: Background The relationship between IL-35 genes polymorphism and susceptibility to coronary heart disease has not been tested in the largest Han population in China. The aim of this study was to explore the effect of single nucleotide polymorphisms (SNPs) of interleukin-35 (IL-35) genes and its relationship with environment on the risk of coronary heart disease (CHD). Methods We performed Hardy–Weinberg equilibrium test on the control group. The relationship between the four SNPs of IL-35 genes and the risk of coronary heart disease was studied by multivariate logistic regression. The best interaction was identified with generalized multifactor dimensionality reduction (GMDR). Logistic regression was used for investigation on association between four SNPs and CHD risk. Results Logistic regression analysis showed that the C allele of rs428253 and the G allele of rs2243115 were independently correlated with increased risk of CHD, and adjusted ORs (95% CI) were 1.91 (1.28–2.64) and 1.80 (1.30–2.23), respectively. However, there was no significant association between CHD and rs4740 or rs568408. GMDR model indicated a best model for CHD risk consisted of rs428253 and current smoking, which scored 10/10 for both the sign test and cross-validation consistency (p = 0.010). Therefore, this overall multi-dimensional model had the highest cross-validation consistency, regardless of how the data were divided. This provided an evidence of gene–environment interaction effects. We also found that current smokers with rs428253-GC/CC genotype have the highest CHD risk, compared to never smokers with rs428253-GG genotype, OR (95% CI) = 3.04 (1.71–4.41), after adjustment for age, gender, hypertension, T2DM and alcohol consumption status. Conclusions In this study, the C allele of rs428253 and the G allele of rs2243115, and the interaction rs428253 and current smoking were correlated with increased risk of CHD.
Databáze: OpenAIRE
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