Development of a protocol to provide prolonged general anesthesia to pregnant sows
| Autor: | Ernest J. Tacchi, W. S. Roberts, Jeffrey L. Ardell, Randall W. Powell, Donna Lynn Dyess, John J. Ferrara |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Sufentanil Swine medicine.medical_treatment Anesthesia General Models Biological Xylazine Pregnancy medicine Anesthesia Obstetrical Animals Ketamine Sufentanil Citrate Propofol Mechanical ventilation Vecuronium Bromide Isoflurane business.industry Cesarean Section Cannula Surgery Sodium thiopental Anesthesia Female business medicine.drug |
| Zdroj: | Journal of investigative surgery : the official journal of the Academy of Surgical Research. 7(3) |
| ISSN: | 0894-1939 |
| Popis: | This study was designed to determine whether a pregnant sow could be maintained under conditions of prolonged general anesthesia in order to provide access to prematurely delivered piglets for purposes of acute experimentation. Fifteen time-dated pregnant (90% of gestation) sows were preanesthetized with intramuscular xylazine (Rompun Mobay Pharmaceutical, Shawnee, KS)/ketamine (Aveco Pharmaceutical, Fort Dodge, IA). After anesthesia was induced with intravenous sodium thiopental, the animals underwent tracheotomy and mechanical ventilation. The electrocardiogram was monitored externally; systemic arterial pressure was supervised by the insertion of a brachial artery cannula; and urine output was determined by inserting a cystostomy tube. A surgical plane of anesthesia was achieved by the "balanced" technique: an inhalant, isoflurane, supplemented by intravenous doses of sufentanil citrate, propofol (Stuart Pharmaceuticals, Wilmington, DE), and vecuronium. Sows were maintained under general anesthesia for an average of 12 h; piglets were delivered, one or two at a time, by a modified cesarean section technique. No sows or piglets were lost to anesthetic complications. It is concluded that, with appropriate precautions, pregnant sows can be anesthetized for a prolonged period of time, and provide viable premature neonates for acute experimentation. |
| Databáze: | OpenAIRE |
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