Tumor-infiltrating lymphocytes contain a higher proportion of FOXP3+ T lymphocytes in cervical cancer
| Autor: | Hong Nerng Ho, Tzu Yun Kuo, Ming Yih Wu |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty cervical cancer FOXP3 Fluorescent Antibody Technique Uterine Cervical Neoplasms chemical and pharmacologic phenomena Cervical intraepithelial neoplasia T-Lymphocytes Regulatory Interleukin 21 Lymphocytes Tumor-Infiltrating Humans Medicine Cytotoxic T cell IL-2 receptor Medicine(all) Cervical cancer lcsh:R5-920 Microscopy Confocal Cluster of differentiation business.industry Tumor-infiltrating lymphocytes Forkhead Transcription Factors hemic and immune systems General Medicine medicine.disease Molecular biology Lymphatic Metastasis cervical intraepithelial neoplasm Female lcsh:Medicine (General) business Treg cells |
| Zdroj: | Journal of the Formosan Medical Association, Vol 110, Iss 9, Pp 580-586 (2011) |
| ISSN: | 0929-6646 |
| DOI: | 10.1016/j.jfma.2011.07.005 |
| Popis: | Background/PurposeThe subpopulations and functions of tumor-infiltrating lymphocytes (TILs) from cervical cancer (CC) are altered. Dysfunction of TIL could be partially because of the inhibition by regulatory T (Treg) cells. FOXP3 is the control gene for the Treg cells.MethodsWe investigated the distribution of TILs and FOXP3+ cells in CC (n = 10) and cervical intraepithelial neoplasia (n = 8) tissues. Double-immunofluorescence and confocal-based image quantitative microscopic analysis were used to calculate the number of cluster of differentiation (CD)4+CD25+FOXP3+ Treg cells around the tumor cells.ResultsThe CD4+CD25+FOXP3+ phenotype of Treg cells was accumulated around the tumor cells. CC contains a significantly higher proportion of the FOXP3+ T cells than in cervical intraepithelial neoplasia (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|