Neoneurogenesis: tumors may initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis
| Autor: | Kerstin Lang, Theodore L. Drell, Daniel Palm, Kurt S. Zaenker, Frank Entschladen |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Biology Stem cell marker Metastasis Neovascularization chemistry.chemical_compound Mice Norepinephrine Neurotrophic factors Neoplasms medicine Animals Humans Nerve Growth Factors Neoplasm Metastasis Neurotransmitter Neurons Neurotransmitter Agents Neovascularization Pathologic Cancer General Medicine medicine.disease Prognosis Lymphangiogenesis Disease Models Animal chemistry Disease Progression Lymph Nodes medicine.symptom Free nerve ending |
| Zdroj: | Medical hypotheses. 67(1) |
| ISSN: | 0306-9877 |
| Popis: | Malignant tumors frequently release angiogenic factors, which lead to the vascularization of the tumor, a process called neoangiogenesis. This neoangiogenesis provides sufficient nourishment of the tumor when it exceeds a certain size. Recently, a similar mechanism has been postulated for the development of new lymph vessels in tumors, termed lymphangiogenesis. Thus, tumors get access to the circulation and lymph drainage like any other growing or regenerating tissue. Furthermore, it has been hypothesized that neoangiogenesis and lymphangiogenesis support metastasis development. Elaborating on this model, we herein present strong arguments for the new theory that tumors initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis. For this process, we coin the term neoneurogenesis. It is likely that neoneurogenesis further supports the formation of metastases, since the ingrown nerve endings can release neurotransmitters which enhance the metastasis development. Strikingly, the presence of nerve cell markers in tumor tissues has been shown to be a prognostic marker for the course of a cancer disease, and we have recently reported on the metastasis-increasing function of the neurotransmitter norepinephrine in a mouse model. |
| Databáze: | OpenAIRE |
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