Frequency and prognostic significance of p16INK4A protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma
| Autor: | Stephen Kleid, Neil Vallance, Benjamin Solomon, June Corry, Damien Urban, Danny Rischin, Christopher Angel, Bernard Lyons, Richard J. Young, Tim A. Iseli |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology Larynx Cancer Research Pathology Transcription Genetic p16 RNA in situ hybridisation Cohort Studies Medicine Prospective Studies Papillomaviridae human papillomavirus Prospective cohort study Aged 80 and over biology Middle Aged Prognosis laryngeal squamous cell carcinoma medicine.anatomical_structure Head and Neck Neoplasms immunohistochemistry Cohort Carcinoma Squamous Cell outcome RNA Viral Immunohistochemistry Female Cohort study Adult medicine.medical_specialty In situ hybridization Internal medicine Biomarkers Tumor Carcinoma Humans RNA Messenger Laryngeal Neoplasms Molecular Diagnostics Cyclin-Dependent Kinase Inhibitor p16 Aged Squamous Cell Carcinoma of Head and Neck business.industry Papillomavirus Infections Oncogene Proteins Viral biology.organism_classification medicine.disease DNA Viral business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2015.59 |
| Popis: | Background: Human papillomavirus (HPV) infection is a powerful prognostic biomarker in a subset of head and neck squamous cell carcinomas, specifically oropharyngeal cancers. However, the role of HPV in non-oropharyngeal sites, such as the larynx, remains unconfirmed. Methods: We evaluated a cohort of 324 laryngeal squamous cell carcinoma (LSCC) patients for the expression of p16INK4A (p16) protein by immunohistochemistry (IHC) and for high-risk HPV E6 and E7 mRNA transcripts by RNA in situ hybridisation (ISH). p16 expression and HPV status were correlated with clinicopathological features and outcomes. Results: Of 307 patients assessable for p16 IHC, 20 (6.5%) were p16 positive. Females and node-positive patients were more likely to be p16 positive (P |
| Databáze: | OpenAIRE |
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