Evaluation of LKB1 and Serine-Glycine Metabolism Pathway Genes (SHMT1 and GLDC) Expression in AML
| Autor: | Parinaz Khadem, Fateme Mezginejad, Mohammad Hossein Mohammadi, Mehdi Allahbakhshian Farsani |
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| Rok vydání: | 2020 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty Hematology business.industry Regulator Myeloid leukemia 030204 cardiovascular system & hematology Human genetics Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine Gene expression medicine Cancer research Original Article Epigenetics skin and connective tissue diseases business Gene 030215 immunology |
| Zdroj: | Indian J Hematol Blood Transfus |
| ISSN: | 0974-0449 0971-4502 |
| Popis: | LKB1 is a significant tumor suppressor and epigenetic regulator playing a vital role in different types of cancers. SHMT1 and GLDC are two critical genes of the epigenetic pathway influenced by LKB1. As epigenetic is the major cause of AML pathogenesis, this study aimed at investigating LKB1, SHMT1, and GLDC gene expression levels in acute myeloid leukemia patients. The present study was conducted on LKB1, SHMT1, and GLDC gene expression levels in 60 de novo AML samples and 30 normal controls using real-time RT-PCR. The results showed that LKB1 and SHMT1 have respectively a significantly lower (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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