T cell Lines Responding to Mycoplasma arthritidis and Chondrocytes in the Mycoplasma arthritidis Infection of Rats
| Autor: | Martin Runge, Karin Busche, Michael Schlesier, Alfred Binder, Helga Kirchhoff |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
T-Lymphocytes
T cell Immunology In Vitro Techniques Lymphocyte Activation Major histocompatibility complex medicine.disease_cause Chondrocyte Cell Line Microbiology Mycoplasma Antigen MHC class I medicine Animals Immunology and Allergy Mycoplasma Infections Arthritis Infectious biology Cell growth Hematology T lymphocyte Rats Cartilage Phenotype medicine.anatomical_structure Rats Inbred Lew biology.protein Female |
| Zdroj: | Immunobiology. 181:398-405 |
| ISSN: | 0171-2985 |
| DOI: | 10.1016/s0171-2985(11)80508-5 |
| Popis: | CD 4+ T cell lines responding specifically to Mycoplasma (M.) arthritidis were established from spleen and lymph nodes of a Lewis rat infected with M.arthritidis.The T cell response to M.arthritidis was MHC class II-restricted.M.arthritidis-reactive T cell lines also responded to syngeneic chondrocytes suggesting that M.arthritidis and chondrocytes may share a common antigenic structure. The T cell lines reacting with chondrocytes may play an important role in the chronic stage of the M.arthritidis-induced arthritis of rats by maintaining immune reactions initiated by M.arthritidis antigens and originally established to eliminate the mycoplasmas.These autoimmune reactions could perpetuate after disappearance of the mycoplasmas and possibly last for the entire lifetime. |
| Databáze: | OpenAIRE |
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