Effect of diminazene aceturate, levamisole and vitamin C combination therapy in rats experimentally infected with Trypanosoma brucei brucei
| Autor: | Adieme Ijeoma Chekwube, Ugochukwu, Emmanuel Ikenna Ugochukwu, Emmanuel Ikenna Ugochukwu, Emmanuel Ikenna, R. C. Ezeokonkwo, Ezeh Ikenna Onyema |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Vitamin Combination therapy Diminazene aceturate Trypanosoma brucei brucei Cell volume Ascorbic Acid Trypanosoma brucei Pharmacology Parasite Load Body Temperature Hemoglobins Leukocyte Count chemistry.chemical_compound Animals Medicine Vitamin C Medicine(all) biology business.industry Body Weight Rectal temperature General Medicine Levamisole biology.organism_classification Trypanocidal Agents Rats Trypanosomiasis African chemistry Drug Therapy Combination Therapy business Diminazene medicine.drug |
| Zdroj: | Asian Pacific Journal of Tropical Medicine. 7(6):438-445 |
| ISSN: | 1995-7645 |
| DOI: | 10.1016/s1995-7645(14)60071-7 |
| Popis: | Objective To investigate the effect of diminazene aceturate (DA) alone or in combination with either levamisole and/or Vitamin C in albino rats experimentally infected with Trypanosoma brucei brucei . Methods Thirty adult male albino rats, randomly assigned into 6 groups (A-F) of 5 rats each were used. They were either infected with 1×10 6 trypanosomes intraperitoneally (groups A-E) or uninfected (group F). The different groups were treated respectively as follows: group A-with 3.5 mg/kg DA; group B-3.5 mg/kg DA and 7.5 mg/kg levamisole; group C-3.5 mg/kg DA and 100 mg/kg vitamin C; and group D-3.5 mg/kg DA and 7.5 mg/kg levamisole and 100 mg/kg vitamin C. Group E was left untreated. Parameters assessed include: rectal temperature, body weight changes, packed cell volume (PCV), Haemoglobin concentration (Hb), total leucocyte count (TLC) differential leucocyte count (DLC), parasitaemia, clinical signs and survivability. Results Average pre-patent period of 5 days was recorded. Parasites in the blood were cleared in all treated groups (A-D) within 48 hours post treatment (PT). Untreated rats in group E died between 25 and 32 days post infection (PI). Relapse was not recorded in all the treated groups (A-D). The initial reduction in PCV, Hb, TLC and increases in rectal temperature following infection were reversed by the treatments. The rats that received drug combinations (groups B, C and D) showed faster and higher recovery rates than the uninfected control and group A. Conclusions Levamisole and/or Vitamin C combination with DA were more effective in the treatment of rats infected with Trypanosoma brucei brucei . |
| Databáze: | OpenAIRE |
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