Efficacy of a new oral lubricant solution in the management of psychotropic drug-induced xerostomia: a randomized controlled trial
| Autor: | Anne-Claude Coudert, Phillip Preshaw, Yves Tillet, Stéphane Mouly, Frantz Oberli, Jean-Baptiste Orler, Jean-François Bergmann |
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| Rok vydání: | 2007 |
| Předmět: |
Drug
Adult Glycerol Male medicine.medical_specialty Adolescent media_common.quotation_subject Dentistry Administration Oral Xerostomia Speech Disorders law.invention Subjective sensation Taste Disorders stomatognathic system Randomized controlled trial Oral administration law Internal medicine Surveys and Questionnaires Lubrication medicine Humans Pharmacology (medical) Clinical efficacy media_common Aged Aged 80 and over Psychotropic Drugs business.industry Mouth Mucosa Saliva Artificial Middle Aged Silicon Dioxide stomatognathic diseases Psychiatry and Mental health Psychotropic drug Female business Deglutition Disorders |
| Zdroj: | Journal of clinical psychopharmacology. 27(5) |
| ISSN: | 0271-0749 |
| Popis: | Xerostomia is a subjective sensation of mouth dryness often occurring as an unwanted effect of psychotropic drugs.The clinical efficacy and acceptability of a new oxygenated glycerol triester (OGT) oral spray (1 or 2 sprays up to 4 times daily) in the treatment of xerostomia was compared with those of a commercially available artificial saliva substitute (ASS [Saliveze]) in a 2-week, open-labeled, randomized, parallel-group study. Clinical assessment of xerostomia included evaluation of mouth dryness by means of a 10-cm-long visual analog scale, objective blinded assessment of the oral tissue condition by a dental hygienist by means of a 4-point ordinal scale, and subjective patient-based assessment of dry mouth symptoms by means of dichotomous responses to a questionnaire. [Day 14 - baseline] patient-based mouth dryness score was the primary end point.Seventy-four patients (41 women and 33 men, 44 +/- 15 years) undergoing long-term psychotropic drug treatment were consecutively enrolled. At day 14, OGT resulted in better efficacy than ASS in mouth dryness score (mean difference, 1.2 +/- 0.4; P = 0.006), speech difficulties (mean difference, 1.2 +/- 0.4; P = 0.005), taste (mean difference, 1.1 +/- 0.4; P = 0.02), and overall mouth condition (mean difference, 1.4 +/- 0.9; P = 0.005). Taste of OGT was better than that of ASS (mean difference, 1.4 +/- 0.6; P = 0.04), as was OGT acceptability (mean difference, 1.4 +/- 0.9; P = 0.005).Oxygenated glycerol triester lubricant oral spray was superior to a commercially available ASS in improving xerostomia and overall condition of the oral tissue. |
| Databáze: | OpenAIRE |
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