Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases

Autor:	Toshihiro Kita, Kazuo Kitamura
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Heart Failure Physiology Hypertension Pulmonary Adrecizumab Myocardial Infarction Review Article Translational research Clinical trial Adrenomedullin PEGylated adrenomedullin Cardiovascular Diseases Internal Medicine Humans Cardiology and Cardiovascular Medicine
Zdroj:	Hypertension Research
ISSN:	1348-4214 0916-9636
Popis:	Adrenomedullin (AM) is a vasodilative peptide with various physiological functions, including the maintenance of vascular tone and endothelial barrier function. AM levels are markedly increased during severe inflammation, such as that associated with sepsis; thus, AM is expected to be a useful clinical marker and therapeutic agent for inflammation. However, as the increase in AM levels in cardiovascular diseases (CVDs) is relatively low compared to that in infectious diseases, the value of AM as a marker of CVDs seems to be less important. Limitations pertaining to the administrative route and short half-life of AM in the bloodstream (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc3ed8e5de6749fb02705778297f47e http://europepmc.org/articles/PMC8732970 Zobrazit plný text záznamu Full text from SpringerLink