Brain Tumor Enhancement in MR Imaging at 3 Tesla
| Autor: | Stefan O. Schoenberg, Jonmenjoy Biswas, Val M. Runge, Maximilian F. Reiser, Bernd J. Wintersperger |
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| Rok vydání: | 2007 |
| Předmět: |
Contrast enhancement
animal diseases Brain tumor Contrast Media Gadolinium Sensitivity and Specificity Magnetics Animal model Gradient recalled echo medicine Animals Radiology Nuclear Medicine and imaging medicine.diagnostic_test Brain Neoplasms business.industry Reproducibility of Results Magnetic resonance imaging Glioma General Medicine Image enhancement Image Enhancement medicine.disease Magnetic Resonance Imaging Mr imaging Rats Inbred F344 Rats nervous system diseases Female Nuclear medicine business |
| Zdroj: | Investigative Radiology. 42:558-563 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/rli.0b013e31803e8b3f |
| Popis: | The purpose of this study was to compare brain and tumor signal characteristics of T1-weighted turbo spin-echo (TSE) and gradient recalled echo (GRE) sequence techniques at 3 T compared to TSE at 1.5 T, focusing on the detection of contrast enhancement, in a standardized animal model of a brain glioma.Twelve rats with implanted brain gliomas were evaluated at 1.5 and 3 T using matched hardware configurations. At 1.5 T, scanning was performed using a TSE sequence optimized for field strength (480/15 milliseconds; 125 Hz/Px) with postcontrast scans acquired at multiple time points after gadoteridol injection (0.1 mmol/kg). At 3 T, scanning was performed using the 1.5 T equivalent TSE as well as with TSE and GRE techniques optimized for 3 T. Signal-to-noise ratio (SNR) of brain and tumor and tumor contrast-to-noise ratio (CNR) were evaluated for all techniques at both field strengths.Postcontrast tumor SNR (63.7 +/- 10.8 vs. 29.5 +/- 4.3; P0.0001) and brain SNR (35.8 +/- 1.5 vs. 19.1 +/- 0.7; P0.0001) showed significant increase at 3 T using matched TSE. Comparing TSE optimized to each field strength (for optimized gray-white contrast), tumor and brain SNR still showed a significant increase at 3 T of 73% and 56%, respectively (both P0.0001). Comparing TSE at 1.5 T and GRE at 3 T, tumor SNR increased by 105%, whereas brain SNR increased by 141% (both P0.0001). Tumor CNR with matched TSE increased by 168% (P0.0001), with optimized TSE by 111% (P0.0001), and with GRE at 3 T versus TSE at 1.5 T by 36% (P0.001). With additional adjustments for echo time the gain in tumor CNR for 2D GRE may again reach 60%.With TSE at 3 T, the SNR gain comes close to the theoretically expected doubling with an even higher tumor CNR increase. In a clinical like setting at 3 T, where a T1w GRE sequence is used, tumor CNR gain is limited. Contrast dose should therefore not be decreased at 3 T. |
| Databáze: | OpenAIRE |
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